Haploinsufficiency of Apc leads to ineffective hematopoiesis. - Wikidata - wikimedia - TriplyDB

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

http://www.wikidata.org/entity/Q42198272

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Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells Global transcriptome analyses of human and murine terminal erythroid differentiation.Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Genetic pathways leading to therapy-related myeloid neoplasms.Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Microwaving blood as a non-destructive technique for haemoglobin measurements on microlitre samples.Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis.Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.Unraveling the molecular pathophysiology of myelodysplastic syndromes.Molecular dissection of the 5q deletion in myelodysplastic syndrome.Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes Secondary Adult Acute Myeloid Leukemia: a Review of Our Evolving Understanding of a Complex Disease Process.Therapy-related myeloid neoplasms: when genetics and environment collide.β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).Wnt Signaling in Normal and Malignant Stem Cells.Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.Hematopoietic stem cell development requires transient Wnt/β-catenin activity.Clonal evolution in myelodysplastic syndromes with isolated del(5q): the importance of genetic monitoring.Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q.Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model.Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant.

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Haploinsufficiency of Apc leads to ineffective hematopoiesis.

http://www.wikidata.org/entity/Q42198272

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

2010年學術文章

@zh

2010年學術文章

@zh-hant

name

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@en

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@nl

type

label

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@en

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@nl

prefLabel

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@en

Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@nl

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Haploinsufficiency of Apc leads to ineffective hematopoiesis.

@en

P2093

Anthony A Fernald

http://www.w3.org/2001/XMLSchema#string

Jianghong Wang

http://www.w3.org/2001/XMLSchema#string

John Anastasi

http://www.w3.org/2001/XMLSchema#string

Michelle M Le Beau

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Zhijian Qian

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P2860

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

Nucleophosmin regulates the stability and transcriptional activity of p53

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

Age and manifestation related symptoms in familial adenomatous polyposis.

Roles of eukaryotic ribosomal proteins in maturation and transport of pre-18S rRNA and ribosome function.

Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

A critical role for Apc in hematopoietic stem and progenitor cell survival

Role of nucleophosmin in embryonic development and tumorigenesis

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20065296

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haploinsufficiency

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3372947

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