Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor.
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Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical diseaseOrganocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition.Vicinal diamination of alkenes under Rh-catalysis.P53 mdm2 inhibitors.Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis.Cinchonidinium acetate as a convenient catalyst for the asymmetric synthesis of cis-stilbenediamines.Achiral counterion control of enantioselectivity in a Brønsted acid-catalyzed iodolactonization.Palladium-Catalyzed α-Arylation of Aryl NitromethanesPreparation of H,(4) PyrrolidineQuin-BAM (PBAM).Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.Synthesis of the reported structure of piperazirum using a nitro-Mannich reaction as the key stereochemical determining stepPreparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.The p53-MDM2/MDMX axis - A chemotype perspective.On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.Methods for direct alkene diamination, new & old.Enantioselective methodologies using N-carbamoyl-imines.Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps.Organocatalytic Asymmetric Synthesis of Dihydroisoquinolinones via a One-Pot Aza-Henry-Hemiaminalization-Oxidation SequenceBifunctional iminophosphorane organocatalysts for enantioselective synthesis: application to the ketimine nitro-Mannich reaction.Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitorEnantioselective bifunctional iminophosphorane catalyzed sulfa-Michael addition of alkyl thiols to unactivated β-substituted-α,β-unsaturated estersPalladium-catalyzed nitromethylation of aryl halides: an orthogonal formylation equivalent.Minimizing the amount of nitromethane in palladium-catalyzed cross-coupling with aryl halides.MDM2 Antagonists Counteract Drug-Induced DNA Damage.Enantioselective trapping of phosphoramidate ammonium ylides with imino esters for synthesis of 2,3-diaminosuccinic acid derivatives.Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.One-Pot Three-Component Synthesis of Vicinal Diamines via In Situ Aminal Formation and Carboamination.Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.Chiral ammonium betaine-catalyzed highly stereoselective aza-henry reaction of α-aryl nitromethanes with aromatic N-Boc imines.Metal-templated chiral Brønsted base organocatalysis.One-pot multicomponent nitro-Mannich reaction using a heterogeneous catalyst under solvent-free conditions.Cinchona-Derived Picolinamides: Effective Organocatalysts for Stereoselective Imine Hydrosilylation
P2860
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P2860
Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@en
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@nl
type
label
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@en
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@nl
prefLabel
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@en
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@nl
P2860
P356
P1433
P1476
Catalytic, Enantioselective Sy ...... , a Potent p53/MDM2 Inhibitor.
@en
P2093
Tyler A Davis
P2860
P304
P356
10.1039/C1SC00061F
P577
2011-01-01T00:00:00Z