Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. - Wikidata - wikimedia - TriplyDB

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

http://www.wikidata.org/entity/Q42208253

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Metabolism of kidney cancer: from the lab to clinical practice Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion The role of PHD2 mutations in the pathogenesis of erythrocytosis.Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.Therapies in inborn errors of oxidative metabolism.The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.NRF2 and cancer: the good, the bad and the importance of context.The Succinated Proteome of FH-Mutant Tumours Oncometabolites: linking altered metabolism with cancer.Multiple hits for the association of uterine fibroids on human chromosome 1q43.Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer.Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.Insights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas.Inborn and acquired metabolic defects in cancer.Revisiting the TCA cycle: signaling to tumor formation Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression.Biological detection by optical oxygen sensing.Rare insights into cancer biology.Nature's inordinate fondness for metabolic enzymes: why metabolic enzyme loci are so frequently targets of selection.Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways Leiomyoma cutis: a focused review on presentation, management, and association with malignancy.Mitochondria and the hallmarks of cancer.Altered metabolite levels in cancer: implications for tumour biology and cancer therapy.Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.The emerging role of fumarate as an oncometabolite.TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State.Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes Undernutrition upregulates fumarate hydratase in the rat nucleus accumbens.

P2860

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P2860

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

http://www.wikidata.org/entity/Q42208253

description

2010 nî lūn-bûn

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name

Dysregulation of hypoxia pathw ...... tive mitochondrial metabolism.

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Dysregulation of hypoxia pathw ...... tive mitochondrial metabolism.

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Dysregulation of hypoxia pathw ...... tive mitochondrial metabolism.

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Dysregulation of hypoxia pathw ...... tive mitochondrial metabolism.

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Dysregulation of hypoxia pathw ...... tive mitochondrial metabolism.

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Human Molecular Genetics

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John Griffiths

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Kieran Clarke

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Linda O'Flaherty

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Lisa C Heather

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Melroy X Miranda

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Yuen-Li Chung

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P2860

Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini.

Expanding chemical biology of 2-oxoglutarate oxygenases

Mitochondrial tumour suppressors: a genetic and biochemical update

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

Hypoxia--a key regulatory factor in tumour growth

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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