Kinetics and mechanism of the serine beta-lactamase catalyzed hydrolysis of depsipeptides.
about
Inactivation of the RTEM-1 cysteine beta-lactamase by iodoacetate. The nature of active-site functional groups and comparisons with the native enzymeEstB from Burkholderia gladioli: A novel esterase with a β-lactamase fold reveals steric factors to discriminate between esterolytic and β-lactam cleaving activitySubstituted aryl malonamates as new serine beta-lactamase substrates: structure-activity studiesInhibition of class A and C beta-lactamases by diaroyl phosphates.Class C beta-lactamases operate at the diffusion limit for turnover of their preferred cephalosporin substrates.Serendipitous discovery of α-hydroxyalkyl esters as β-lactamase substrates.Deacylation transition states of a bacterial DD-peptidase.Accumulation of acyl-enzyme in DD-peptidase-catalysed reactions with analogues of peptide substrates.Effect of side-chain amide thionation on turnover of beta-lactam substrates by beta-lactamases. Further evidence on the question of side-chain hydrogen-bonding in catalysis.Reaction of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with beta-lactams and acyclic substrates: kinetics in homogeneous solution.Evidence from a mutant beta-lactamase for the mechanism of beta-lactamase-catalysed depsipeptide aminolysis.Nucleophilic re-activation of the PC1 beta-lactamase of Staphylococcus aureus and of the DD-peptidase of Streptomyces R61 after their inactivation by cephalosporins and cephamycins.On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptidesRelative specificities of a series of beta-lactam-recognizing enzymes towards the side-chains of penicillins and of acyclic thioldepsipeptides.Chromogenic depsipeptide substrates for beta-lactamases and penicillin-sensitive DD-peptidases.Accumulation of acyl-enzyme intermediates during turnover of penicillins by the class A beta-lactamase of Staphylococcus aureus PC1.Evidence for an oxyanion hole in serine beta-lactamases and DD-peptidases.The mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.Structure-activity relationships in the inhibition of serine beta-lactamases by phosphonic acid derivatives.Effect of the 3'-leaving group on turnover of cephem antibiotics by a class C beta-lactamase.Phosphonate monoester inhibitors of class A beta-lactamases.
P2860
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P2860
Kinetics and mechanism of the serine beta-lactamase catalyzed hydrolysis of depsipeptides.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@en
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@nl
type
label
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@en
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@nl
prefLabel
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@en
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@nl
P356
P1433
P1476
Kinetics and mechanism of the ...... d hydrolysis of depsipeptides.
@en
P2093
Govardhan CP
P304
P356
10.1021/BI00386A021
P407
P577
1987-06-01T00:00:00Z