Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

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Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

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Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

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Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

@en

Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

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Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

@en

Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

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P1476

Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.

@en

P2093

Ai-Hua Zhang

http://www.w3.org/2001/XMLSchema#string

Jian Xu

http://www.w3.org/2001/XMLSchema#string

Kun Shen

http://www.w3.org/2001/XMLSchema#string

Ling Sun

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Si-Han Zhang

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Xiao-Hong Liu

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Yan Ma

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Yong-Mei He

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Yun-Deng Wu

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Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.

Crystal structure refinement with SHELXL.

Use of intensity quotients and differences in absolute structure refinement.

SHELXT - integrated space-group and crystal-structure determination.

Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.

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P304

821-824

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P31

scholarly article

P356

10.1107/S2056989017006661

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P433

Pt 6

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P478

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P577

2017-05-09T00:00:00Z

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P698

28638635

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P932

5458300

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