Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient - Wikidata - wikimedia - TriplyDB

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

http://www.wikidata.org/entity/Q42228192

about

Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling.Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair.Current insights into LMNA cardiomyopathies: Existing models and missing LINCs ESCRT-dependent control of membrane remodelling during cell division.Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.Inhibition of N-acetyltransferase 10 using remodelin attenuates doxorubicin resistance by reversing the epithelial-mesenchymal transition in breast cancer.Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.Causes and consequences of genomic instability in laminopathies: replication stress and interferon response.

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Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

http://www.wikidata.org/entity/Q42228192

description

2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@en

Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@nl

type

label

Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@en

Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@nl

prefLabel

Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@en

Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@nl

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Prelamin A impairs 53BP1 nucle ...... nd disrupting the Ran gradient

@en

P2093

Andrew M Cobb

http://www.w3.org/2001/XMLSchema#string

Derek T Warren

http://www.w3.org/2001/XMLSchema#string

Sonal Srivastava

http://www.w3.org/2001/XMLSchema#string

Yiwen Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging

A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei

NTF2 mediates nuclear import of Ran.

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.

Phenotype and course of Hutchinson-Gilford progeria syndrome

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Genomic instability in laminopathy-based premature aging

A pathway linking oxidative stress and the Ran GTPase system in progeria.

P304

1039-1050

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scholarly article

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10.1111/ACEL.12506

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6

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15

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Stephen P Jackson

Delphine Larrieu

Richard P Bowater

Catherine Shanahan

Andrew John Oliver Smith

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2016-07-27T00:00:00Z

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27464478

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5114580

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