about
Rules for biocatalyst and reaction engineering to implement effective, NAD(P)H-dependent, whole cell bioreductionsHost cell and expression engineering for development of an E. coli ketoreductase catalyst: enhancement of formate dehydrogenase activity for regeneration of NADH.Bioprocess design guided by in situ substrate supply and product removal: process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol.Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies.Comparison of Scheffersomyces stipitis strains CBS 5773 and CBS 6054 with regard to their xylose metabolism: implications for xylose fermentationWhole-cell bioreduction of aromatic alpha-keto esters using Candida tenuis xylose reductase and Candida boidinii formate dehydrogenase co-expressed in Escherichia coli.The role of Cys108 in Trigonopsis variabilis d-amino acid oxidase examined through chemical oxidation studies and point mutations C108S and C108D.Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis.Targeting the substrate binding site of E. coli nitrile reductase QueF by modeling, substrate and enzyme engineering.Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant.Tyr-51 is the proton donor-acceptor for NAD(H)-dependent interconversion of xylose and xylitol by Candida tenuis xylose reductase (AKR2B5).Integration of enzyme, strain and reaction engineering to overcome limitations of baker's yeast in the asymmetric reduction of alpha-keto esters.Studying non-covalent enzyme carbohydrate interactions by STD NMR.Identification of Candida tenuis xylose reductase as highly selective biocatalyst for the synthesis of aromatic alpha-hydroxy esters and improvement of its efficiency by protein engineering.Integration of whole-cell reaction and product isolation: Highly hydrophobic solvents promote in situ substrate supply and simplify extractive product isolation.Harnessing Candida tenuis and Pichia stipitis in whole-cell bioreductions of o-chloroacetophenone: stereoselectivity, cell activity, in situ substrate supply and product removal.Scale-up and intensification of (S)-1-(2-chlorophenyl)ethanol bioproduction: economic evaluation of whole cell-catalyzed reduction of o-chloroacetophenone.Candida tenuis xylose reductase catalyzed reduction of aryl ketones for enantioselective synthesis of active oxetine derivatives.Candida tenuis xylose reductase catalysed reduction of acetophenones: the effect of ring-substituents on catalytic efficiencyEnzyme identification and development of a whole-cell biotransformation for asymmetric reduction of o-chloroacetophenone
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Regina Kratzer
@ast
Regina Kratzer
@en
Regina Kratzer
@es
Regina Kratzer
@nl
Regina Kratzer
@sl
type
label
Regina Kratzer
@ast
Regina Kratzer
@en
Regina Kratzer
@es
Regina Kratzer
@nl
Regina Kratzer
@sl
prefLabel
Regina Kratzer
@ast
Regina Kratzer
@en
Regina Kratzer
@es
Regina Kratzer
@nl
Regina Kratzer
@sl
P106
P1153
6603820295
P21
P31
P496
0000-0002-9318-1247