Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08. - Wikidata - wikimedia - TriplyDB

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.

http://www.wikidata.org/entity/Q42246343

about

CD28 co-stimulation in T-cell homeostasis: a recent perspective Emerging Therapies for Rheumatoid Arthritis Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model TCR signaling fuels T(reg) cell suppressor function.T Cells of Infants Are Mature, but Hyporeactive Due to Limited Ca2+ Influx.Interleukin-2/Anti-Interleukin-2 Immune Complex Attenuates Cardiac Remodeling after Myocardial Infarction through Expansion of Regulatory T Cells.Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade.Stabilizing human regulatory T cells for tolerance inducing immunotherapy.Role of receptor occupancy assays by flow cytometry in drug development.Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy.CD28 Costimulation: From Mechanism to Therapy.Drug Development of Therapeutic Monoclonal Antibodies.Cytokines: The Good, the Bad, and the Deadly.In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account.Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells.Short-term cytokine stimulation reveals regulatory T-cells with down-regulated Foxp3 expression in human peripheral blood.In vitro polyclonal activation of conventional T cells with a CD28 superagonist protects mice from acute graft versus host disease.The return of the prodigal son and the extraordinary development route of antibody TGN1412 - lessons for drug development and clinical pharmacology.Characterization of T-cell subpopulations in patients with chronic rhinosinusitis with nasal polyposis.Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation.A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.CD28 between tolerance and autoimmunity: the side effects of animal models.

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P2860

Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.

http://www.wikidata.org/entity/Q42246343

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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type

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Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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P1433

European Journal of Immunology

P1476

Human regulatory T cells are s ...... 28 superagonist TGN1412/TAB08.

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P2093

Alexey A Matskevich

http://www.w3.org/2001/XMLSchema#string

Dmitry Tyrsin

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Paula S Römer

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Paula Tabares

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Sergej Chuvpilo

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Susanne Berr

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Thomas Hünig

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Yury Fedotov

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P2860

Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis.

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

The molecular basis of TCR germline bias for MHC is surprisingly simple

CTLA-4 control over Foxp3+ regulatory T cell function

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.

Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.

Interleukin 2 signaling is required for CD4(+) regulatory T cell function.

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

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1225-1236

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10.1002/EJI.201343967

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4

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44

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Hermann Einsele

Hans-Peter Tony

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2014-02-01T00:00:00Z

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259490919

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24374661

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