Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. - Wikidata - wikimedia - TriplyDB

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

http://www.wikidata.org/entity/Q42250384

about

Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices Endothelial cell-cell adhesion during zebrafish vascular development Vascular anomalies: from genetics toward models for therapeutic trials Lack of CCM1 induces hypersprouting and impairs response to flow Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.PDCD10 gene mutations in multiple cerebral cavernous malformations The pathobiology of vascular malformations: insights from human and model organism genetics.KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma.ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis.The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.Apicobasal polarity of brain endothelial cells.Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice.Loss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth.Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.A Novel CCM2 Gene Mutation Associated with Familial Cerebral Cavernous Malformation Introduction to cerebral cavernous malformation: a brief review.Cerebral cavernous malformation proteins at a glance.STRIPAK complexes: structure, biological function, and involvement in human diseases.Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management.SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.A murine toolbox for imaging the neurovascular unit.PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations.Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.Cerebral cavernous malformations arise independent of the heart of glass receptor.Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo.CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.

P2860

Q24314844-FBC023BD-7E00-49C7-9ABA-9B8B7418D303 Q26849566-9ACEF3EC-F913-4066-859C-6335EF817C40 Q26996223-078F14AE-47C4-4130-8009-ECCB69F99888 Q27005949-84796EAB-89E7-48A8-92F7-F59BD3DE681F Q27025402-F59198D8-F83A-4911-AD86-1C9712C4439C Q27301327-E5E1B979-AA78-4759-93BC-FA8B3E41186E Q27329910-E42DFB86-68BF-4F40-896F-16EFA39C1895 Q30278010-2EFAB04D-D9E8-464E-A671-9579B4CBEA22 Q30389638-5B3F3C2E-AC63-4E19-B29A-686372AB2A6F Q30542261-03DA6083-6F1D-45F6-8DB4-A2C45E3D3EE8 Q34209951-63299D35-89D1-427C-945A-98903A299033 Q34420456-6974F591-FF66-4086-9568-816999409135 Q34544980-167F6F94-CB60-49A1-840B-207C23B716D3 Q34552843-D1E961D9-98A0-4B8B-A935-0289670A65F1 Q35167117-FDD39945-38BF-427A-8B2B-967A4677C2E4 Q35816668-4EC57A71-3DCF-4225-A35A-23A904C35126 Q35876785-BA461833-5DF8-4ACD-BB67-67158102843F Q36109992-78C856E1-1DB1-4C82-A0B0-19BC4D6940AA Q36595837-1821B0A4-2966-4888-B76C-82A479894012 Q36600362-EC498B87-C27D-4645-AF1D-E40B9D84BDD6 Q36619170-ACECFA1F-378E-4687-A136-9E62AF4B2F5D Q36705891-12161E59-1404-4D2D-B582-ABB6A6024874 Q37239068-FD972B52-B82C-4A15-B58F-E782F199CBF9 Q37270784-32CAA222-26A3-49C4-9951-346D1FD86048 Q37351147-2FF6E317-F6B5-4D7F-828B-A8BAB8C8955F Q37583343-FDE958B5-82F7-40F1-82E9-C8244836DEE1 Q37590616-56558253-394C-4125-95B3-66AF356D6715 Q37618688-2855BA18-CF88-4A68-9998-B4CFDC0C0096 Q37722299-70F650A9-3ED0-4FDE-8FAD-D8C364A793BC Q38003193-BAF8AD4A-B189-4E6B-910E-71AA1E0B44E1 Q38124367-FD74743F-7560-4733-B619-F2ABADE3B3AF Q38263461-D5D7CAA3-0D70-487A-AA67-CAA8F68318CC Q38268858-B899DD8F-44A2-44C4-92FC-DC9F8AF5092A Q38622980-86FB0C78-1CD0-49A0-8824-26E937EC0B18 Q38957623-C33DF53A-78E9-472C-AEAC-51B7F66B18F5 Q39113906-5D5FD0B9-2F9E-46A4-B9D2-E0B7E5A4D878 Q41517629-2C4DEF78-AB23-4182-9B05-A17746C0AA5F Q42414313-A0B47DC0-CF19-4E30-9912-1EE2A36D22C5 Q47035963-AAE144CA-8DE4-48A6-B984-A1B231C9B605 Q47369895-48C7ADDA-B47F-4F8B-B8BE-AC2E55E8E7A0

P2860

Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

http://www.wikidata.org/entity/Q42250384

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Mutations in 2 distinct geneti ...... vernous malformations in mice.

@en

type

label

Mutations in 2 distinct geneti ...... vernous malformations in mice.

@en

prefLabel

Mutations in 2 distinct geneti ...... vernous malformations in mice.

@en

P1433

Q42250384-A37DDE5B-D104-492E-BCF7-721F6E50B976

P1476

Q42250384-03C80103-65A1-4D6B-BD86-00FE3F0C8C8D

P2093

Q42250384-0449462A-B169-4D1D-A833-1A6EA712DFA0

Q42250384-08B409E3-F1C8-44D2-9DFC-FB9B3F42FF2D

Q42250384-0EDAD672-1B57-4F05-862B-E23F7D4A4C31

Q42250384-175ACE54-4908-4B6D-8F98-6A782F25755B

Q42250384-36880C23-F5D1-4D41-BA53-D89CA374D3EE

Q42250384-41F6AB28-37A6-4844-99C9-2EC8E684BE50

Q42250384-44CD3FB8-7CDF-4F2E-A5C6-71F7E4A4CF91

Q42250384-54A13925-F723-4332-B7DA-4EEDCE95EF47

Q42250384-570D1082-3696-4FFB-98B0-E27EF300C05D

Q42250384-8D65BAF4-6A51-42D8-BC06-1788A71F4049

P2860

Q42250384-12528032-7350-44C3-BCA2-13A6ADD1B90F

Q42250384-1690D70C-3DB4-44A6-AED9-B3C892561AE1

Q42250384-1D5B8790-243B-4F45-BA72-5C4FB1E3B4E9

Q42250384-1D86B42F-5380-42F0-96DA-52F106D3B307

Q42250384-1F8A95BF-DC77-4ABC-A405-762ABE60BEBA

Q42250384-217FFDAC-C605-48EB-882E-06815EEAEDCB

Q42250384-2247546A-E640-44E6-A879-4E06CE696C16

Q42250384-2A7C878C-B4B0-479C-812B-10FB015CC7D8

Q42250384-2F2F06F2-EAFB-410A-BD55-E33A23D5F515

Q42250384-34D7134D-83F6-4F42-8598-41A1159B667E

P304

Q42250384-EFCE8B31-2D08-4347-97F8-07857A6A60D7

P31

Q42250384-C5A1E91A-D993-4DD9-A2D4-908314487A97

P356

Q42250384-8EC13B06-868D-488C-B0ED-34B0366B685B

P407

Q42250384-5714814E-365B-4019-B2EA-0171F9BEA930

P433

Q42250384-07599CB9-ED24-4435-9687-E9F06A99118D

P478

Q42250384-C305CDD5-5499-4495-8D18-24BC519FDF1E

P50

Q42250384-1293FE39-4752-4DD6-99CD-EDB462F04B84

Q42250384-C39A063B-7680-42CB-8820-10F3FE05B4E4

P577

Q42250384-113CC2A2-3E10-4564-8DC4-60FCB90F89B6

P698

Q42250384-BC95E45F-386B-4EC4-B468-761D5E96F4C1

P932

Q42250384-3F8CD443-F489-4B13-9A2D-DACCC272EAEF

P356

P1433

Journal of Clinical Investigation

P1476

Mutations in 2 distinct geneti ...... avernous malformations in mice

@en

P2093

Alexandra C H Smith

http://www.w3.org/2001/XMLSchema#string

Allie H Grossmann

http://www.w3.org/2001/XMLSchema#string

Amber N Stratman

http://www.w3.org/2001/XMLSchema#string

Anastasia Sacharidou

http://www.w3.org/2001/XMLSchema#string

Christopher C Gibson

http://www.w3.org/2001/XMLSchema#string

Dean Y Li

http://www.w3.org/2001/XMLSchema#string

George E Davis

http://www.w3.org/2001/XMLSchema#string

Jing Ling

http://www.w3.org/2001/XMLSchema#string

Kevin J Whitehead

http://www.w3.org/2001/XMLSchema#string

M Patricia Revelo

http://www.w3.org/2001/XMLSchema#string

P2860

PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

Mutation and cancer: statistical study of retinoblastoma

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis

Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation

P304

1871-1881

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI44393

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

121

http://www.w3.org/2001/XMLSchema#string

P50

P577

2011-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21490399

http://www.w3.org/2001/XMLSchema#string

P932

3083782

http://www.w3.org/2001/XMLSchema#string