Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
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Search for non-nucleoside inhibitors of HIV-1 reverse transcriptase using chemical similarity, molecular docking, and MM-GB/SA scoringNon-nucleoside reverse transcriptase inhibitors: the NNRTI boom.6-[(2-Methyl-phen-yl)sulfan-yl]-5-propyl-pyrimidine-2,4(1H,3H)-dione.Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives.Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors.Crystal structure of 6-chloro-5-iso-propyl-pyrimidine-2,4(1H,3H)-dione3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integraseComputationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents5-Propyl-6-(p-tolyl-sulfan-yl)pyrimidine-2,4(1H,3H)-dione.4-(2-Meth-oxy-phen-yl)piperazin-1-ium 6-chloro-5-isopropyl-2,4-dioxopyrimidin-1-ideDesign, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives.Design, synthesis, and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives.Synthesis and in vitro antitumor activity of new substituted thiopyrimidine acyclic nucleosides and their thioglycoside analogs.6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.Antiviral and cytostatic evaluation of the novel 6-acyclic chain substituted thymine derivatives.TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.Synthesis and antiviral properties of arabino and ribonucleosides of 1,3-dideazaadenine, 4-nitro-1,3-dideazapurine and diketopiperazine.N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate.Crystal structures of 4-phenyl-piperazin-1-ium 6-chloro-5-ethyl-2,4-dioxopyrimidin-1-ide and 4-phenyl-piperazin-1-ium 6-chloro-5-isopropyl-2,4-dioxopyrimidin-1-ide.Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils.Synthesis and anti-HIV-1 activity of new fluoro-HEPT analogues: an investigation on fluoro versus hydroxy substituents.The synthesis of novel 6,5- and 6,6-membered fused heterocyclic compounds derived from thymine.Eurotiumins A⁻E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452.
P2860
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P2860
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Synthesis and antiviral activity of 6-benzyl analogs of 1-[
@nl
Synthesis and antiviral activi ...... d selective anti-HIV-1 agents.
@en
type
label
Synthesis and antiviral activity of 6-benzyl analogs of 1-[
@nl
Synthesis and antiviral activi ...... d selective anti-HIV-1 agents.
@en
prefLabel
Synthesis and antiviral activity of 6-benzyl analogs of 1-[
@nl
Synthesis and antiviral activi ...... d selective anti-HIV-1 agents.
@en
P2093
P356
P1476
Synthesis and antiviral activi ...... d selective anti-HIV-1 agents.
@en
P2093
De Clercq E
Miyasaka T
Takashima H
P304
P356
10.1021/JM00015A008
P407
P577
1995-07-01T00:00:00Z