Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.
about
Model for the peptide-free conformation of class II MHC proteins.Peptide exchange in MHC molecules.Interpretation of biphasic dissociation kinetics for isomeric class II major histocompatibility complex-peptide complexes.A pH-sensitive histidine residue as control element for ligand release from HLA-DR moleculesBinding interactions between peptides and proteins of the class II major histocompatibility complex.Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins.Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides.A structural transition in class II major histocompatibility complex proteins at mildly acidic pH.Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.SKN-1 domain folding and basic region monomer stabilization upon DNA bindingMechanistic understanding and significance of small peptides interaction with MHC class II molecules for therapeutic applications.Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.Molecular mechanisms of peptide loading by the tumor rejection antigen/heat shock chaperone gp96 (GRP94).Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1.Thermodynamic analysis of the increased stability of major histocompatibility complex class II molecule I-Ek complexed with an antigenic peptide at an acidic pH.Contribution of a single hydrogen bond between betaHis81 of MHC class II I-E(k) and the bound peptide to the pH-dependent thermal stability.Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding.Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM.
P2860
Q33342783-1ACDDBCF-BB1E-472C-8777-E9BFAFDC7B3EQ33815435-12119B63-1AFE-4749-A814-1D71EF2F6BCEQ34171654-F50742C4-2198-4EAC-A0B3-1255DAC531F0Q34430383-E56E730C-7527-43EE-9B1E-D64C8E014ED2Q34540061-648862FF-9B5D-473B-A8D6-7831C8D0B402Q36048493-59440151-B8AB-4209-B054-04B9BDE8C31FQ36285397-5622E1C9-9CC1-4A9B-A960-8EC0D30D15CDQ36366080-25A7B7D4-5353-4CCD-958B-BCF31CABB9B6Q36396787-0203AEEE-F109-487F-80D7-628AE54EBD04Q36720788-8D3FE108-F7E9-4AD9-8E67-68A934A030CFQ37367381-1AF3BDAF-D0EF-4686-B5AF-9248524ED5E5Q38869738-6346B7F4-54A8-4112-B194-7BB4224EAEDEQ40358752-13E2F094-DEB3-41D0-8DF6-3C5897646E21Q42599516-68960204-3AFF-4FBF-B4EE-0DDF7D543343Q42617265-9825736A-512C-4D6E-AC52-1C6E554F59F6Q42694508-E21B352C-377E-430A-8906-87C02160DC64Q44735993-4223E0C1-FD8E-4750-86EF-49845D727C4FQ44752464-24B6A287-2543-44AB-8F3C-982404980FD4Q46972584-9AC0DA82-7649-466C-B4D6-1A50BAFBBC0B
P2860
Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Evidence for a conformational ...... e antigen binding is enhanced.
@en
Evidence for a conformational ...... e antigen binding is enhanced.
@nl
type
label
Evidence for a conformational ...... e antigen binding is enhanced.
@en
Evidence for a conformational ...... e antigen binding is enhanced.
@nl
prefLabel
Evidence for a conformational ...... e antigen binding is enhanced.
@en
Evidence for a conformational ...... e antigen binding is enhanced.
@nl
P2093
P2860
P356
P1476
Evidence for a conformational ...... e antigen binding is enhanced.
@en
P2093
D A Wettstein
J J Boniface
N L Allbritton
P2860
P304
P356
10.1084/JEM.183.1.119
P407
P577
1996-01-01T00:00:00Z