PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
about
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors.Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-Bclx strategies through Mcl-1 down-regulationSystematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
P2860
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@en
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@nl
type
label
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@en
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@nl
prefLabel
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@en
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@nl
P2093
P2860
P50
P1476
PIK3CA mutations enable target ...... OR-mediated MCL-1 translation.
@en
P2093
Alexander Yllanes
Daniel P Nussbaum
Donald P McDonnell
Elizabeth K Zieser-Misenheimer
Elizabeth M Stein
Holly M Alley
Jennifer P Tingley
Jim C Leeds
Kimberly L Blackwell
Kris C Wood
P2860
P304
P356
10.1126/SCITRANSLMED.AAE0348
P407
P577
2016-12-01T00:00:00Z