Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
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Activation of the orphan receptor RIP14 by retinoidsIdentification of ligands and coligands for the ecdysone-regulated gene switchOral retinoids and rexinoids in cutaneous T-cell lymphomasDefining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor Ligand Binding DomainMethyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and preventionMethyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid ToxicityActivation of mammalian retinoid X receptors by the insect growth regulator methopreneInduction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular targetRetinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptorExpression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoproteinLow dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson's disease.Creation and discovery of ligand-receptor pairs for transcriptional control with small moleculesSynthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging.Characterization of a molecular switch system that regulates gene expression in mammalian cells through a small molecule.Potential retinoid x receptor agonists for treating Alzheimer's disease from traditional chinese medicine.The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cellsRetinoid-dependent pathways suppress myocardial cell hypertrophy.Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation.Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation.Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensorsTherapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndromeRetinoid activation of retinoic acid receptors but not of retinoid X receptors promotes cellular differentiation and replication of human cytomegalovirus in embryonal cellsCoexpression of nuclear receptor partners increases their solubility and biological activities.Modeling, synthesis and biological evaluation of potential retinoid X receptor-selective agonists: novel halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)Targeting truncated RXRα for cancer therapy.Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cellsThe receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal.Treatment of cutaneous T-cell lymphoma with retinoids.All-trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor- dependent signaling pathway.Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydroNovel retinoic acid receptor ligands in Xenopus embryos.The modification of natural products for medical use.Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.The utility of bexarotene in mycosis fungoides and Sézary syndrome.Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase.Novel all trans-retinoic Acid derivatives: cytotoxicity, inhibition of cell cycle progression and induction of apoptosis in human cancer cell lines.Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation.
P2860
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P2860
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Synthesis and structure-activi ...... receptor-selective retinoids.
@en
Synthesis and structure-activi ...... receptor-selective retinoids.
@nl
type
label
Synthesis and structure-activi ...... receptor-selective retinoids.
@en
Synthesis and structure-activi ...... receptor-selective retinoids.
@nl
prefLabel
Synthesis and structure-activi ...... receptor-selective retinoids.
@en
Synthesis and structure-activi ...... receptor-selective retinoids.
@nl
P2093
P356
P1476
Synthesis and structure-activi ...... receptor-selective retinoids.
@en
P2093
Goldman ME
P304
P356
10.1021/JM00044A014
P407
P577
1994-09-01T00:00:00Z