about
CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progressionUsing steered molecular dynamics to predict and assess Hsp70 substrate-binding domain mutants that alter prion propagationA proteomic approach to investigating gene cluster expression and secondary metabolite functionality in Aspergillus fumigatusMolecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatusSelf-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxinGlobal transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activityAssessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes.RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatusResistance is not futile: gliotoxin biosynthesis, functionality and utility.A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress.Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.Chaperoning prions: the cellular machinery for propagating an infectious protein?The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.The yeast prion protein Ure2: structure, function and folding.Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2nuvA, an Aspergillus nidulans gene involved in DNA repair and recombination, is a homologue of Saccharomyces cerevisiae RAD18 and Neurospora crassa uvs-2.Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate bindingThe Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatusThe double life of the ribosome: When its protein folding activity supports prion propagation.Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus.Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation.Gliotoxin effects on fungal growth: mechanisms and exploitation.Reconstructing the fungal tree of life using phylogenomics and a preliminary investigation of the distribution of yeast prion-like proteins in the fungal kingdom.Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence.Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger.(-)-epigallocatechin-3-gallate inhibits fibrillogenesis of chicken cystatin.Myricetin prevents fibrillogenesis of hen egg white lysozyme.Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity.Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus.Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.Yeast models for amyloid disease.Deletion of the Hsp70 chaperone gene SSB causes hypersensitivity to guanidine toxicity and curing of the [PSI+] prion by increasing guanidine uptake in yeast.Molecular dynamics simulation to investigate the impact of disulfide bond formation on conformational stability of chicken cystatin I66Q mutant.Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase.The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine.The β6/β7 region of the Hsp70 substrate-binding domain mediates heat-shock response and prion propagation.Steered molecular dynamics simulations on the binding of the appendant structure and helix-β2 in domain-swapped human cystatin C dimer.Steered molecular dynamics simulation of the binding of the bovine auxilin J domain to the Hsc70 nucleotide-binding domain.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Gary W Jones
@ast
Gary W Jones
@en
Gary W Jones
@es
Gary W Jones
@nl
Gary W Jones
@sl
غاري دبليو جونز
@ar
type
label
Gary W Jones
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Gary W Jones
@en
Gary W Jones
@es
Gary W Jones
@nl
Gary W Jones
@sl
غاري دبليو جونز
@ar
prefLabel
Gary W Jones
@ast
Gary W Jones
@en
Gary W Jones
@es
Gary W Jones
@nl
Gary W Jones
@sl
غاري دبليو جونز
@ar
P106
P21
P31
P496
0000-0002-7565-934X