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A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repairDistinct roles for cyclins E and A during DNA replication complex assembly and activationC-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrixCiz1 promotes mammalian DNA replicationCiz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitroDifferential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon-junction microarray.The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.Variant Ciz1 is a circulating biomarker for early-stage lung cancerCiz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor.Relationship between DNA replication and the nuclear matrix.Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication.Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.Regulation of eukaryotic DNA replication.Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halosCyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication.DNA induces conformational changes in a recombinant human minichromosome maintenance complexA quantitative immunoassay for lung cancer biomarker CIZ1b in patient plasma.Cardiomyocyte--specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart.Reconstitution of the cellular response to DNA damage in vitro using damage-activated extracts from mammalian cells.Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process.Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells.Protein kinase inhibition in G2 causes mammalian Mcm proteins to reassociate with chromatin and restores ability to replicate.Xenopus replication assays.A protein kinase-dependent block to reinitiation of DNA replication in G2 phase in mammalian cells.Preparation of the Nuclear Matrix for Parallel Microscopy and Biochemical Analyses.CIZ1-F, an alternatively spliced variant of the DNA replication protein CIZ1 with distinct expression and localisation, is overrepresented in early stage common solid tumoursThe Nuclear Matrix: Fractionation Techniques and AnalysisEffect of exogenous DNA fragments on human cell extract-mediated DNA repair synthesisRequirement for the replication protein SSB in human DMA excision repairMaintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term cultureVisualization of Hidden Epitopes at the Inactive X Chromosome
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Dawn Coverley
@ast
Dawn Coverley
@en
Dawn Coverley
@es
Dawn Coverley
@nl
Dawn Coverley
@sl
type
label
Dawn Coverley
@ast
Dawn Coverley
@en
Dawn Coverley
@es
Dawn Coverley
@nl
Dawn Coverley
@sl
prefLabel
Dawn Coverley
@ast
Dawn Coverley
@en
Dawn Coverley
@es
Dawn Coverley
@nl
Dawn Coverley
@sl
P108
P106
P21
P31
P496
0000-0001-8262-7023
P569
2000-01-01T00:00:00Z