Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
about
Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibitionDiscovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition
P2860
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@en
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@nl
type
label
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@en
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@nl
prefLabel
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@en
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@nl
P2093
P2860
P356
P1433
P1476
Coinhibition of the deubiquiti ...... macroglobulinemia tumor cells
@en
P2093
A Chanan-Khan
B Edenfield
P2860
P2888
P356
10.1038/BCJ.2016.93
P577
2016-11-04T00:00:00Z
P6179
1002662542