PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors.

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Q54976860-C5A75738-9A0E-4AC5-A7ED-F841DB7F4A19

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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2017 nî lūn-bûn

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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Aubrey S Smith

http://www.w3.org/2001/XMLSchema#string

Bulent Arman Aksoy

http://www.w3.org/2001/XMLSchema#string

Chrystal M Paulos

http://www.w3.org/2001/XMLSchema#string

Jeffrey E Hammerbacher

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Lillian R Neal

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Megan M Wyatt

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Michelle H Nelson

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P2860

P110delta, a novel phosphoinositide 3-kinase in leukocytes

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

FOXO transcription factors throughout T cell biology

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

A human memory T cell subset with stem cell-like properties

PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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1221

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scholarly article

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10.3389/FIMMU.2017.01221

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P478

http://www.w3.org/2001/XMLSchema#string

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Stefanie R Bailey

Kinga Majchrzak

Jacob S Bowers

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2017-09-29T00:00:00Z

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P698

29033940

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5626814

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

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P1433

P1476

P2093

P2860

P304

P31

P356

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P478

P50

P577

P698

P932