about
Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitorsPhysioSpace: relating gene expression experiments from heterogeneous sources using shared physiological processesBayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant PopulationsPrincipal components analysis and the reported low intrinsic dimensionality of gene expression microarray dataTranslational learning from clinical studies predicts drug pharmacokinetics across patient populations.Enabling multiscale modeling in systems medicine.Identification of clinically relevant protein targets in prostate cancer with 2D-DIGE coupled mass spectrometry and systems biology network platform.Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid LeukemiaPower-laws and the use of pluripotent stem cell lines.Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells.A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.Robust PBPK/PD-Based Model Predictive Control of Blood Glucose.Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.Stem Cell Differentiation as a Non-Markov Stochastic Process.Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity.Investigation of potential traces of pluripotency in germinal-center-derived B-cell lymphomas driven by MYC.A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System.A systematic atlas of chaperome deregulation topologies across the human cancer landscape.Inflammatory processes during acute respiratory distress syndrome: a complex system.Whither systems medicine?Few inputs can reprogram biological networks.An elastic network model to identify characteristic stress response genes.Smart Medical Information Technology for Healthcare (SMITH)From hype to reality: data science enabling personalized medicineSemi-empirical process modelling with integration of commercial modelling toolsMethodological challenges in translational drug response modeling in cancer: A systematic analysis with FORESEE
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հետազոտող
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A Schuppert
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P1153
24345112100
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P496
0000-0003-3783-6605