Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited.
about
Application of cross-species PET imaging to assess neurotransmitter release in brainCerebral 5-HT release correlates with [(11)C]Cimbi36 PET measures of 5-HT2A receptor occupancy in the pig brainModeling of PET data in CNS drug discovery and development.Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking study.A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [¹¹C]PBR28 and [¹⁸F]PBR111 for TSPO imaging.Serotonin 2A receptor agonist binding in the human brain with [¹¹C]Cimbi-36.Decreased prefrontal cortical dopamine transmission in alcoholismEvaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers.Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primatesAn Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989.Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain.Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050.PET imaging reveals sex differences in kappa opioid receptor availability in humans, in vivoKinetic modeling of (11)C-LY2795050, a novel antagonist radiotracer for PET imaging of the kappa opioid receptor in humans.Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis.Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [(11) C]ABP688 PET imagingEvaluation of dopamine D₂/₃ specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release.Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release.Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study.Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates.Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors.Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.Measurement of Bmax and Kd with the glycine transporter 1 radiotracer ¹⁸F-MK6577 using a novel multi-infusion paradigm.A hybrid deconvolution approach for estimation of in vivo non-displaceable binding for brain PET targets without a reference regionBrain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler.PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates.Glycine transporter type 1 occupancy by bitopertin: a positron emission tomography study in healthy volunteers.Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase InhibitorsKinetic analysis of drug-target interactions with PET for characterization of pharmacological hysteresis.Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding.Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.Evaluation of [(11)C]MRB for assessment of occupancy of norepinephrine transporters: Studies with atomoxetine in non-human primatesMeasuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot.The PET Radioligand 18F-FIMX Images and Quantifies Metabotropic Glutamate Receptor 1 in Proportion to the Regional Density of Its Gene Transcript in Human Brain.Synthesis and evaluation of 11C-LY2795050 as a κ-opioid receptor antagonist radiotracer for PET imagingThe 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to α1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region.Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brainUnexpectedly high affinity of a novel histamine H(3) receptor antagonist, GSK239512, in vivo in human brain, determined using PET.11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain.
P2860
Q26865012-5C01BAED-8A1B-4486-88D5-A6B3748B21F2Q30303267-371535FA-7963-4225-8F9E-0B1DAFDAF92AQ30623699-DD5A2096-CEF7-44AA-92AA-9011F1D5D921Q33729262-FF35345B-5F93-458B-A9A6-A45A4ED7DE8DQ33851465-8680887A-9049-4EFB-90FC-77BAF7D1B76FQ33851479-23F474D0-D8DE-4F99-B1CC-53418116AD11Q33992499-9063F74C-248F-43F6-AB3B-B9AEB0CE3F3CQ34073200-8D449F0D-2616-46A3-B440-53FC4F4EF064Q34329011-AF8541F8-AB86-462E-A5B9-F98FA183974BQ34357077-3733D9C6-3521-4E15-ABF1-105A25541B99Q34421107-99877CF9-80CC-47DE-9AA7-A00EB2AB030FQ34467002-AEFA2418-997A-44C7-9214-1E47CDFD01DDQ34503799-E0308C8F-97F6-4788-ACAC-2E1CCEED03EFQ34540741-3066C4D5-651B-4D69-A353-34F38B17630DQ34727498-BC5793E1-8D28-4DFD-B656-111389971958Q34765568-BD750DA6-7093-44E3-97A2-A24668E2A322Q35058637-1011638E-A610-49C3-B129-E7516A3D1EB3Q35103315-C07FB6D1-1C67-406E-B39B-83710F16DB96Q35146221-A193F68D-6BE8-4D16-8256-48A643DDD44EQ35448551-72921162-7D24-4579-95E3-207408B8BCF7Q35637965-14512509-4311-4602-8401-25EF92185F0FQ35918576-40905920-90FA-4B70-B240-AE931F4C8EA3Q36275427-F30A0F3B-5C80-4A10-8BB5-4EF45B6F6CEFQ36350490-D25B7648-9ADA-4AFC-BDCE-81DF93876ACAQ36359775-ED383E92-E645-42E4-8487-53EA995F05ADQ36433744-610D8872-8530-4D4D-AF3F-09EB6F4A7AC4Q36522071-E60F0AE5-28B9-4BF2-8F0E-D6C7B42F374EQ36540072-8757B781-7A6D-46BC-B909-D7FA66F23847Q36634033-327CCF22-BDB2-4202-B8AB-9DDB647E8561Q36839978-E06E7D5E-7228-4055-9321-8C485E43E018Q37000214-6E170829-D6EC-4121-81D4-292AB6669FFEQ37008461-2D4F87F5-3A9A-4927-AD58-5B0ED27F1E23Q37009798-9231EA5A-1DE3-4CA9-9685-5615786AE9F5Q37172834-3FEC6599-35F9-4125-8E97-DB7C240A0359Q37172845-6F0A37E9-1695-448C-AA4B-28D04B212595Q37177752-EDE3BEFC-7B55-4314-9F6F-7A693EB77A55Q37449400-C225E3FE-1EF3-4370-A2AA-24995A6790DEQ37560665-60E1E9E2-27C8-4DDB-AC07-F2A6FFD067F8Q37635268-DE3F5165-5186-4E44-952A-E8332D28840CQ38794304-907E5ACE-EBF3-4751-83C2-5CD0636D1982
P2860
Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@en
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@nl
type
label
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@en
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@nl
prefLabel
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@en
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@nl
P2093
P2860
P356
P1476
Measuring drug occupancy in th ...... n: the Lassen plot re-visited.
@en
P2093
Eugenii A Rabiner
Marc Laruelle
Mark Slifstein
Vincent J Cunningham
P2860
P356
10.1038/JCBFM.2009.190
P577
2009-09-09T00:00:00Z