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Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes.Toxicogenomics directory of chemically exposed human hepatocytes.In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-β1-induced cellular damageManufactured nanomaterials: categorization and approaches to hazard assessment.A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity.Decrease of global methylation improves significantly hepatic differentiation of Ad-MSCs: possible future application for urea detoxification.In vitro mammalian metabolism of the mitosis inhibitor zoxamide and the relationship to its in vitro toxicity.Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells.Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay.Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype.Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition.Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity
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description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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name
Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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Georg Damm
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P106
P2038
Georg_Damm
P21
P31
P496
0000-0002-2104-8076