Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
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Signaling in Effector Lymphocytes: Insights toward Safer ImmunotherapyThe paracaspase MALT1: biological function and potential for therapeutic inhibitionLongitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.DNAM-1 control of natural killer cells functions through nectin and nectin-like proteins.T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signalingT-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.Progress towards the development of SH2 domain inhibitors.Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion.Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production.NF-κB signaling pathways regulated by CARMA family of scaffold proteins.The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.The Paracaspase MALT1.The SYK tyrosine kinase: a crucial player in diverse biological functions.The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generationLine of attack: NK cell specificity and integration of signals.NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition.Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.Differential requirement for CARMA1 in agonist-selected T-cell development.Cross-regulation of signaling by ITAM-associated receptors.Biochemical signaling pathways for memory T cell recall.Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.The natural killer cell: a further innate mediator of gouty inflammation?MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivoMolecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy.Regulation of NF-κB signaling by caspases and MALT1 paracaspase.From MALT lymphoma to the CBM signalosome: three decades of discovery.Transcriptional control of natural killer cell differentiation and function.MALT1 protease: a new therapeutic target in B lymphoma and beyond?L-CBM signaling in lymphocyte development and functionNeuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor κB activation.Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells.Expansion of cytotoxic natural killer cells using irradiated autologous peripheral blood mononuclear cells and anti-CD16 antibodyMultiple protein domains mediate interaction between Bcl10 and MALT1.Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells.ADAPted secretion of cytokines in NK cells.
P2860
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P2860
Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Multiple ITAM-coupled NK-cell ...... y control cytokine production.
@en
Multiple ITAM-coupled NK-cell ...... y control cytokine production.
@nl
type
label
Multiple ITAM-coupled NK-cell ...... y control cytokine production.
@en
Multiple ITAM-coupled NK-cell ...... y control cytokine production.
@nl
prefLabel
Multiple ITAM-coupled NK-cell ...... y control cytokine production.
@en
Multiple ITAM-coupled NK-cell ...... y control cytokine production.
@nl
P2093
P2860
P1433
P1476
Multiple ITAM-coupled NK-cell ...... ly control cytokine production
@en
P2093
Christian Peschel
Christian Steinberg
Christina Grupp
Dan R Littman
Dominikus Strasser
Hairong Huo
Jürgen Ruland
Nicole Hannesschläger
Olaf Gross
Stephanie Zimmermann
P2860
P304
P356
10.1182/BLOOD-2007-11-123513
P407
P577
2008-01-11T00:00:00Z