Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.
about
Heart failure with preserved ejection fraction: emerging drug strategiesA Review of the Giant Protein Titin in Clinical Molecular Diagnostics of CardiomyopathiesTargeting heart failure with preserved ejection fraction: current status and future prospectsThe role of titin and extracellular matrix remodelling in heart failure with preserved ejection fractionIs enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?Titin, a Central Mediator for Hypertrophic Signaling, Exercise-Induced Mechanosignaling and Skeletal Muscle RemodelingTitin-based tension in the cardiac sarcomere: molecular origin and physiological adaptationsHeart failure with preserved ejection fraction: mechanisms, clinical features, and therapiesThe molecular mechanisms of offspring effects from obese pregnancyHeart failure with preserved ejection fractionThe cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fractionCARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complexWhat global diastolic function is, what it is not, and how to measure itDiastolic dysfunctionProtein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardiumIncreased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in miceTetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament propertiesTropomyosin de-phosphorylation in the heart: what are the consequences?Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffnessHeart failure with preserved ejection fraction: molecular pathways of the aging myocardiumPhysiologic basis and pathophysiologic implications of the diastolic properties of the cardiac muscleCalcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient miceDeletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kineticscGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes.Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects.Probing muscle ankyrin-repeat protein (MARP) structure and functionAcute exercise modifies titin phosphorylation and increases cardiac myofilament stiffnessIncreased cardiac myocyte PDE5 levels in human and murine pressure overload hypertrophy contribute to adverse LV remodelingHeart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatmentContribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.The giant protein titin: a regulatory node that integrates myocyte signaling pathways.Redox signaling and cardiac sarcomeresCardiac titin and heart disease.Muscle giants: molecular scaffolds in sarcomerogenesis.Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodelingNitrate's effect on activity tolerance in heart failure with preserved ejection fraction trial: rationale and design
P2860
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P2860
Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Protein kinase G modulates hum ...... rylation of the titin springs.
@en
type
label
Protein kinase G modulates hum ...... rylation of the titin springs.
@en
prefLabel
Protein kinase G modulates hum ...... rylation of the titin springs.
@en
P2093
P1433
P1476
Protein kinase G modulates hum ...... orylation of the titin springs
@en
P2093
Anika Grützner
Christian Andresen
Cris G dos Remedios
Margaret M Redfield
Martina Krüger
Patrick Lang
Sebastian Kötter
Wolfgang A Linke
P356
10.1161/CIRCRESAHA.108.184408
P50
P577
2008-11-20T00:00:00Z