Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
about
The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activationT cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein.Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Cbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase
P2860
Q28141182-B6B7B026-BD5E-4F46-AAE0-CA48A6664523Q30168090-FAC0D297-101D-4178-902D-CCBBC7282640Q30840928-80028788-F875-49AA-A152-43B883F7FD53Q33959661-40C25F42-780E-40E8-8BB8-A590BECF69D6Q34205572-9E8D2CE3-5D43-40B1-A66A-44B86FF01B68Q34405560-0D295B7A-1390-4800-9161-764D3AC49FF2Q36280423-37152AF7-2551-4E8C-8EEF-1A6A9E48F607Q42485920-3FF42A8C-48D9-4359-B8B7-E4518A869BBBQ58179986-113CD22B-B9B2-4D8D-90F5-704630A3DABD
P2860
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
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1999年學術文章
@zh-hant
name
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
@en
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
@nl
type
label
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
@en
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
@nl
prefLabel
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
@en
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
@nl
P2093
P2860
P356
P1476
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z
@en
P2093
P2860
P304
P356
10.1074/JBC.274.8.4883
P407
P50
P577
1999-02-01T00:00:00Z