Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
about
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkThe hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation.The antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants.Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Defining structural and functional dimensions of the extracellular thyrotropin receptor region.Evidence for cooperative signal triggering at the extracellular loops of the TSH receptorNovel insights on thyroid-stimulating hormone receptor signal transduction.The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonistsMonte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain.Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.A Rare Case of Heterozygous Gain of Function Thyrotropin Receptor Mutation Associated with Development of Thyroid Follicular Carcinoma
P2860
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P2860
Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Interactions between the extra ...... y for TSH receptor activation.
@en
Interactions between the extra ...... y for TSH receptor activation.
@nl
type
label
Interactions between the extra ...... y for TSH receptor activation.
@en
Interactions between the extra ...... y for TSH receptor activation.
@nl
prefLabel
Interactions between the extra ...... y for TSH receptor activation.
@en
Interactions between the extra ...... y for TSH receptor activation.
@nl
P356
P1476
Interactions between the extra ...... y for TSH receptor activation.
@en
P2093
Ralf Paschke
Susanne Neumann
P304
P356
10.1530/EJE.1.01891
P50
P577
2005-04-01T00:00:00Z