An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.
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Role of the Extracellular and Intracellular Loops of Follicle-Stimulating Hormone Receptor in Its FunctionStructural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkPrinciples and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signalingThe hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation.The antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants.Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Defining structural and functional dimensions of the extracellular thyrotropin receptor region.Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge RegionEvidence for cooperative signal triggering at the extracellular loops of the TSH receptorRearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor ActivationNovel insights on thyroid-stimulating hormone receptor signal transduction.Congenital neonatal hyperthyroidism caused by germline mutations in the TSH receptor gene.The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism.Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.
P2860
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P2860
An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
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2006年论文
@zh-cn
name
An aromatic environment in the ...... thyrotropin receptor function.
@en
An aromatic environment in the ...... thyrotropin receptor function.
@nl
type
label
An aromatic environment in the ...... thyrotropin receptor function.
@en
An aromatic environment in the ...... thyrotropin receptor function.
@nl
prefLabel
An aromatic environment in the ...... thyrotropin receptor function.
@en
An aromatic environment in the ...... thyrotropin receptor function.
@nl
P2093
P356
P1433
P1476
An aromatic environment in the ...... thyrotropin receptor function.
@en
P2093
P304
P356
10.1210/EN.2005-1138
P407
P50
P577
2006-01-12T00:00:00Z