Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
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Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRINicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptorsThe Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in miceThe Src kinase Lyn is a negative regulator of mast cell proliferationFunctional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells.FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthmaThe limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cellsA minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor.Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.A phase II trial of dasatinib in patients with metastatic castration-resistant prostate cancer treated previously with chemotherapy.The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitmentAdapters in the organization of mast cell signaling.Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor.Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient miceAbsence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses.Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cellsPhospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1An Interaction Library for the FcεRI Signaling NetworkBalanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cellsThe Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinibThe Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase LynThe transcription factor Zeb2 regulates signaling in mast cellsRegulation of mast cell responses in health and disease.Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness.Signal transduction and chemotaxis in mast cellsFunctions of the Lyn tyrosine kinase in health and diseaseAkt-dependent cytokine production in mast cells.Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase.Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxisSingle-cell measurements of IgE-mediated FcεRI signaling using an integrated microfluidic platformRegulation of the mast cell response to the type 1 Fc epsilon receptor.Src family kinases and lipid mediators in control of allergic inflammation.The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine productionThe tyrosine kinase network regulating mast cell activation.The multiple roles of phosphoinositide 3-kinase in mast cell biology.The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cellsNew insights on mast cell activation via the high affinity receptor for IgE
P2860
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P2860
Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-hans
2000年学术文章
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2000年学术文章
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2000年學術文章
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name
Redundant and opposing functio ...... Lyn, in mast cell activation.
@en
Redundant and opposing functio ...... Lyn, in mast cell activation.
@nl
type
label
Redundant and opposing functio ...... Lyn, in mast cell activation.
@en
Redundant and opposing functio ...... Lyn, in mast cell activation.
@nl
prefLabel
Redundant and opposing functio ...... Lyn, in mast cell activation.
@en
Redundant and opposing functio ...... Lyn, in mast cell activation.
@nl
P2093
P1476
Redundant and opposing functio ...... Lyn, in mast cell activation.
@en
P2093
Hartman SE
Kawakami T
Kawakami Y
Maeda-Yamamoto M
Rawlings DJ
Satterthwaite AB
P304
P356
10.4049/JIMMUNOL.165.3.1210
P407
P577
2000-08-01T00:00:00Z