Functional characterization of five constitutively activating thyrotrophin receptor mutations.
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How genetic errors in GPCRs affect their function: Possible therapeutic strategiesConstitutive activation of the thyroid-stimulating hormone receptor (TSHR) by mutating Ile691 in the cytoplasmic tail segment.Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization.Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism.Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonistsGene expression analysis reveals evidence for inactivation of the TGF-beta signaling cascade in autonomously functioning thyroid nodules.
P2860
Q28646207-BF4715FC-CAA3-46C0-9C05-00DECE011549Q33809042-5F573F6E-5617-4F2F-B3AC-53B6EC27BCA9Q36877089-88BACAC0-136C-444E-812B-695DFB37BFA0Q37157903-93687BC0-C9F2-4116-957F-5923823F18FBQ37563887-2F149DB3-7922-4D43-BB61-30514385BD9DQ38077230-2234E7DD-869D-4C31-8220-9C4516C81065Q47249926-C83AA515-756D-4FC2-9BCC-812449009E4C
P2860
Functional characterization of five constitutively activating thyrotrophin receptor mutations.
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2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Functional characterization of ...... yrotrophin receptor mutations.
@en
Functional characterization of ...... yrotrophin receptor mutations.
@nl
type
label
Functional characterization of ...... yrotrophin receptor mutations.
@en
Functional characterization of ...... yrotrophin receptor mutations.
@nl
prefLabel
Functional characterization of ...... yrotrophin receptor mutations.
@en
Functional characterization of ...... yrotrophin receptor mutations.
@nl
P2093
P2860
P1476
Functional characterization of ...... yrotrophin receptor mutations.
@en
P2093
P2860
P304
P356
10.1046/J.1365-2265.2000.01119.X
P577
2000-10-01T00:00:00Z