Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing.
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Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D MicroenvironmentStem Cell Strategies to Evaluate Idiosyncratic Drug-induced Liver InjuryState-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiologyThe Importance of Patient-Specific Factors for Hepatic Drug Response and ToxicityBioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In VitroMicrofluidics-assisted in vitro drug screening and carrier production.TGF-β-independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCCHanging Drop, A Best Three-Dimensional (3D) Culture Method for Primary Buffalo and Sheep Hepatocytes.Organ-on-a-chip platforms for studying drug delivery systems.Bioreactor technologies to support liver function in vitro.Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.An extended ΔCT-method facilitating normalisation with multiple reference genes suited for quantitative RT-PCR analyses of human hepatocyte-like cellsThree-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healingRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids.Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.An evaluation of the latest in vitro tools for drug metabolism studies.Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo.Competency of different cell models to predict human hepatotoxic drugs.The application of engineered liver tissues for novel drug discovery.Advancements in in vitro hepatic models: application for drug screening and therapeutics.3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.Hydrogel-based three-dimensional cell culture for organ-on-a-chip applications.Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics.Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment.HepaRG microencapsulated spheroids in DMSO-free culture: novel culturing approaches for enhanced xenobiotic and biosynthetic metabolism.A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiationCharacterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosisMechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.Characterization of a functional C3A liver spheroid model.Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cellsEndogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.Cell-cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions.Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME TestingEvaluation of the impact of matrix stiffness on encapsulated HepaRG spheroids.Roles of Tumor Microenvironment in Hepatocelluar Carcinoma.
P2860
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P2860
Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Human liver cell spheroids in ...... or repeated-dose drug testing.
@en
Human liver cell spheroids in ...... or repeated-dose drug testing.
@nl
type
label
Human liver cell spheroids in ...... or repeated-dose drug testing.
@en
Human liver cell spheroids in ...... or repeated-dose drug testing.
@nl
prefLabel
Human liver cell spheroids in ...... or repeated-dose drug testing.
@en
Human liver cell spheroids in ...... or repeated-dose drug testing.
@nl
P2093
P2860
P50
P356
P1433
P1476
Human liver cell spheroids in ...... or repeated-dose drug testing.
@en
P2093
Janne Jensen
Petter Björquist
Rui M Tostões
Sofia B Leite
P2860
P304
P356
10.1002/HEP.24760
P407
P577
2012-04-01T00:00:00Z