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Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this responseLocalised micro-mechanical stiffening in the ageing aorta.Tissue section AFM: In situ ultrastructural imaging of native biomolecules.Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions.In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves.Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytesDependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1)How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?Transverse tubules are a common feature in large mammalian atrial myocytes including human.Physiological and pathological modulation of ryanodine receptor function in cardiac muscle.Stability and instability of regulation of intracellular calcium.The control of sarcoplasmic reticulum Ca content in cardiac muscle.Na/Ca exchange: regulator of intracellular calcium and source of arrhythmias in the heart.Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart.The sarcoplasmic reticulum and arrhythmogenic calcium release.Extracellular matrix profiles in the progression to heart failure. European Young Physiologists Symposium Keynote Lecture-Bratislava 2007.The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate.From the ryanodine receptor to cardiac arrhythmias.A functional role for transverse (t-) tubules in the atria.Calcium flux balance in the heart.Sarcoplasmic reticulum Ca-ATPase and heart failure 20 years later.A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes.How does CaMKIIdelta phosphorylation of the cardiac ryanodine receptor contribute to inotropy?Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure.The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes.Heart failure and the ryanodine receptor: does Occam's razor rule?No role for a voltage sensitive release mechanism in cardiac muscle.Differences in intracellular calcium homeostasis between atrial and ventricular myocytes.Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias.Keeping the beat: life without SERCA--is it possible?Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+ current and diastolic [Ca2+]i.Enhanced sarcolemmal Ca2+ efflux reduces sarcoplasmic reticulum Ca2+ content and systolic Ca2+ in cardiac hypertrophy.Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca.Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes.Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes.The ryanodine receptor: cause or consequence of diabetic heart failure?Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content.Photoperiod-dependent modulation of cardiac excitation contraction coupling in the Siberian hamster.
P50
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P50
description
hulumtues
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wetenschapper
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հետազոտող
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name
Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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type
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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Andrew W. Trafford
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P1053
F-2157-2015
P106
P1153
8775326600
P21
P31
P3829
P3835
andrew-trafford
P496
0000-0002-2770-445X