Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.
about
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide SubstrateMicrobicides and other topical agents in the prevention of HIV and sexually transmitted infections.Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.Subtype-associated differences in HIV-1 reverse transcription affect the viral replication.Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.Subtype-specific analysis of the K65R substitution in HIV-1 that confers hypersusceptibility to a novel nucleotide-competing reverse transcriptase inhibitor.Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates."Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition.The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors.Physiological Mg2+ Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro.HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase.Human immunodeficiency virus type 1 recombinant reverse transcriptase enzymes containing the G190A and Y181C resistance mutations remain sensitive to etravirine.
P2860
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P2860
Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
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2006年论文
@zh-cn
name
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@en
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@nl
type
label
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@en
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@nl
prefLabel
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@en
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@nl
P2093
P2860
P356
P1476
Novel nonnucleoside inhibitors ...... type 1 reverse transcriptase.
@en
P2093
Jae Hoon Shim
Jean-Luc Girardet
Michelle Walker
Robert K Hamatake
Zhijun Zhang
P2860
P304
P356
10.1128/AAC.00127-06
P407
P577
2006-08-01T00:00:00Z