The flexibility of a distant loop modulates active site motion and product release in ribonuclease A.
about
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysisEvolutionarily conserved linkage between enzyme fold, flexibility, and catalysisIdentification and analysis of residues contained on β → α loops of the dual-substrate (βα)8phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activityIdentification and characterization of an allosteric inhibitory site on dihydropteroate synthase.The selective interaction between silica nanoparticles and enzymes from molecular dynamics simulationsConformational plasticity surrounding the active site of NADH oxidase from Thermus thermophilus.Structural and functional importance of local and global conformational fluctuations in the RNase A superfamily.Kinetics of conformational changes of the FKF1-LOV domain upon photoexcitation.Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily.What's in your buffer? Solute altered millisecond motions detected by solution NMR.Protein dynamics control the progression and efficiency of the catalytic reaction cycle of the Escherichia coli DNA-repair enzyme AlkBCytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells.An introduction to NMR-based approaches for measuring protein dynamics.Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy.Reengineering rate-limiting, millisecond enzyme motions by introduction of an unnatural amino acid.Network of long-range concerted chemical shift displacements upon ligand binding to human angiogenin.AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate bindingNew Insights into the Role of T3 Loop in Determining Catalytic Efficiency of GH28 Endo-PolygalacturonasesPerturbation of the Conformational Dynamics of an Active-Site Loop Alters Enzyme ActivityConservation of flexible residue clusters among structural and functional enzyme homologuesUsing NMR spectroscopy to elucidate the role of molecular motions in enzyme functionRole of conformational entropy in the activity and regulation of the catalytic subunit of protein kinase A.Networks of Dynamic Allostery Regulate Enzyme FunctionIntegration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.Sequence-specific backbone (1)H, (13)C, and (15)N resonance assignments of human ribonuclease 4.Tautomeric stabilities of 4-fluorohistidine shed new light on mechanistic experiments with labeled ribonuclease A.Modulating Mobility: a Paradigm for Protein Engineering?Complexity of protein energy landscapes studied by solution NMR relaxation dispersion experiments.Direct observation of T4 lysozyme hinge-bending motion by fluorescence correlation spectroscopy.Engineered control of enzyme structural dynamics and function.Conservation of Dynamics Associated with Biological Function in an Enzyme Superfamily.Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily.Atomistic picture of conformational exchange in a T4 lysozyme cavity mutant: an experiment-guided molecular dynamics study† †Electronic supplementary information (ESI) available: Additional figures, a table and details regarding the NMR experiments,
P2860
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P2860
The flexibility of a distant loop modulates active site motion and product release in ribonuclease A.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The flexibility of a distant l ...... uct release in ribonuclease A.
@en
The flexibility of a distant l ...... uct release in ribonuclease A.
@nl
type
label
The flexibility of a distant l ...... uct release in ribonuclease A.
@en
The flexibility of a distant l ...... uct release in ribonuclease A.
@nl
prefLabel
The flexibility of a distant l ...... uct release in ribonuclease A.
@en
The flexibility of a distant l ...... uct release in ribonuclease A.
@nl
P2860
P356
P1433
P1476
The flexibility of a distant l ...... uct release in ribonuclease A.
@en
P2093
J Patrick Loria
Nicolas Doucet
P2860
P304
P356
10.1021/BI900830G
P407
P50
P577
2009-08-01T00:00:00Z