A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. - Wikidata - wikimedia - TriplyDB

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

http://www.wikidata.org/entity/Q42554681

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Hypoxia: The Force that Drives Chronic Kidney Disease Role of HIPK2 in kidney fibrosis HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism RTN1 mediates progression of kidney disease by inducing ER stress.Induction of retinol dehydrogenase 9 expression in podocytes attenuates kidney injury.The primary glomerulonephritides: a systems biology approach.Defining nephrotic syndrome from an integrative genomics perspective.Activation of non-canonical TGF-β1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis.Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition.Fibrogenic cell reversion underlies fibrosis regression in liver.MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets.WSB1 promotes tumor metastasis by inducing pVHL degradation Vascular complications of diabetes: mechanisms of injury and protective factors MicroRNAs in HIV-associated nephropathy (HIVAN).Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase.Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN).Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.Central Nodes in Protein Interaction Networks Drive Critical Functions in Transforming Growth Factor Beta-1 Stimulated Kidney Cells.A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury.Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy.Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile.The role of promoter hypermethylation in fibroblast activation and fibrogenesis.Molecular targets for treatment of kidney fibrosis.Progress in the development of animal models of acute kidney injury and its impact on drug discovery.Unilateral ureteral obstruction: beyond obstruction.How can genetics and epigenetics help the nephrologist improve the diagnosis and treatment of chronic kidney disease patients?Mechanisms of initiation and progression of intestinal fibrosis in IBD.Proteomic biomarkers in kidney disease: issues in development and implementation.Renal allograft fibrosis: biology and therapeutic targets.TSS-Seq analysis of low pH-induced gene expression in intercalated cells in the renal collecting duct Body fluid peptide and protein signatures in diabetic kidney diseases.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression.HIPK2 modification code for cell death and survival.miR-141 regulates TGF-β1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells.

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

http://www.wikidata.org/entity/Q42554681

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name

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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type

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

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Amin R Mazloom

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Edward Y Chen

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Huabao Xiong

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John Cijiang He

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Krishna Ratnam

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Michael J Ross

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Nan Chen

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Peter Y Chuang

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Vivette D'Agati

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Yan Dai

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WikiPathways: pathway editing for the people

HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells

Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways

Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons

Transcription factor Ets-1 is essential for mesangial matrix remodeling

TRANSFAC: transcriptional regulation, from patterns to profiles

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