Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
about
The role of the 70 kDa subunit of human DNA polymerase alpha in DNA replicationATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation.Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation.The replication protein A binding site in simian virus 40 (SV40) T antigen and its role in the initial steps of SV40 DNA replication.Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2APhosphorylation of the herpes simplex virus type 1 origin binding protein.Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylatedSV40 DNA replication: from the A gene to a nanomachine.Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replicationMechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124Purification of the simian virus 40 (SV40) T antigen DNA-binding domain and characterization of its interactions with the SV40 origin.trans-Dominant and non-trans-dominant mutant simian virus 40 large T antigens show distinct responses to ATP.The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.Quantitative analysis of the binding of simian virus 40 large T antigen to DNA.Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding.cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigenDe novo synthesis of budding yeast DNA polymerase alpha and POL1 transcription at the G1/S boundary are not required for entrance into S phaseControl of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I.Protein phosphatase 2A is required for the initiation of chromosomal DNA replication.Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function.The simian virus 40 core origin contains two separate sequence modules that support T-antigen double-hexamer assembly.Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase.The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity.Sequence requirements for the assembly of simian virus 40 T antigen and the T-antigen origin binding domain on the viral core origin of replication.Two regions of simian virus 40 T antigen determine cooperativity of double-hexamer assembly on the viral origin of DNA replication and promote hexamer interactions during bidirectional origin DNA unwinding.Hypoxia blocks in vivo initiation of simian virus 40 replication at a stage preceding origin unwinding.Assembly of T-antigen double hexamers on the simian virus 40 core origin requires only a subset of the available binding sites.Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin.Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro.Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity.Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen.T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.Partial proteolysis of simian virus 40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly.SV40 large T antigen promotes dephosphorylation of p130.A DNA sequence required for geminivirus replication also mediates transcriptional regulation.T antigens encoded by replication-defective simian virus 40 mutants dl1135 and 5080.Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.
P2860
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P2860
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@en
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@nl
type
label
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@en
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@nl
prefLabel
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@en
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@nl
P2093
P2860
P356
P1476
Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A
@en
P2093
P2860
P304
P356
10.1128/MCB.12.11.4883
P407
P577
1992-11-01T00:00:00Z