The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.
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Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membraneProteomic Substrate Identification for Membrane Proteases in the BrainBrain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeuticLRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric StateFocusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's diseaseEnsembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.The proton-pump inhibitor lansoprazole enhances amyloid beta production.Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury.Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.Developmental patterns of DR6 in normal human hippocampus and in Down syndromeA cellular model of amyloid precursor protein processing and amyloid-β peptide production.Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets.Truncated and modified amyloid-beta species.Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site.Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood-brain barrier model.The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments.The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity.Hypothesis: glutaminyl cyclase inhibitors decrease risks of Alzheimer's disease and related dementias.Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavageDetermination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage.The role of astrocytes in amyloid production and Alzheimer's disease.Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Shedding light on designing potential meprin β inhibitors through ligand-based robust validated computational approaches: A proposal to chemists!ADAM10 and BACE1 are localized to synaptic vesicles.Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.
P2860
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P2860
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@en
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@nl
type
label
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@en
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@nl
prefLabel
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@en
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@nl
P2093
P2860
P50
P356
P1476
The metalloprotease meprin β g ...... ted amyloid β peptide species.
@en
P2093
Christoph Becker-Pauly
Claus U Pietrzik
Jessica Bien
Mirsada Causević
Sascha Weggen
Tamara Jefferson
Thorsten Jumpertz
P2860
P304
33304-33313
P356
10.1074/JBC.M112.395608
P407
P577
2012-08-09T00:00:00Z