about
Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybridsCrystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNACovalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersionThe solution structure of double helical arabino nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversionInterdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4GStructure of the parallel duplex of poly(A) RNA: evaluation of a 50 year-old predictionNMR structure of an ethylene interstrand cross-linked DNA which mimics the lesion formed by 1,3-bis(2-chloroethyl)-1-nitrosoureaCross-link structure affects replication-independent DNA interstrand cross-link repair in mammalian cellsProperties of arabinonucleic acids (ANA & 20'F-ANA): implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA.Reductively-sheddable cationic nanocarriers for dual chemotherapy and gene therapy with enhanced release.2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase HStabilization of i-motif structures by 2'-β-fluorination of DNA.Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexesEffect of cross-link structure on DNA interstrand cross-link repair synthesisThe influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS.Studies of a chemically modified oligodeoxynucleotide containing a 5-atom amide backbone which exhibits improved binding to RNA.O(6) -alkylguanine-DNA alkyltransferase-mediated repair of O(4) -alkylated 2'-deoxyuridines.RNA-Binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone structures.Synthesis of building blocks and oligonucleotides containing {T}O4-alkylene-O4{T} interstrand cross-links.Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase.N(4)C-alkyl-N(4)C cross-linked DNA: bending deformations in duplexes that contain a -CNG- interstrand cross-link.Mispair-aligned N3T-alkyl-N3T interstrand cross-linked DNA: synthesis and characterization of duplexes with interstrand cross-links of variable lengths.Accommodation of mispair aligned N3T-ethyl-N3T DNA interstrand cross link.Preparation of covalently linked complexes between DNA and O(6)-alkylguanine-DNA alkyltransferase using interstrand cross-linked DNA.Synthesis, biophysical and repair studies of O6-2'-deoxyguanosine adducts by Escherichia coli OGT.Effect of linker length on DNA duplexes containing a mismatched O6-2'-deoxyguanosine-alkyl interstrand cross-link.Intrastrand base-stacking buttresses widening of major groove in interstrand cross-linked B-DNA.Synthesis and characterization of DNA containing an N1-2'-deoxyinosine-ethyl-N3-thymidine interstrand cross-link: a structural mimic of the cross-link formed by 1,3-bis-(2-chloroethyl)-1-nitrosourea.Synthesis and characterization of DNA duplexes containing an N3T-ethyl-N3T interstrand crosslink in opposite orientations.O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker.Site-specific covalent capture of human O6-alkylguanine-DNA-alkyltransferase using single-stranded intrastrand cross-linked DNA.O4 -Alkylated-2-Deoxyuridine Repair by O6 -Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification.Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase.Structure, flexibility, and repair of two different orientations of the same alkyl interstrand DNA cross-link.Preparation of Intrastrand {G}O(6) -Alkylene-O(6) {G} Cross-Linked Oligonucleotides.O(6)-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage.Synthesis and biophysical properties of arabinonucleic acids (ANA): circular dichroic spectra, melting temperatures, and ribonuclease H susceptibility of ANA.RNA hybrid duplexes.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Christopher J Wilds
@ast
Christopher J Wilds
@en
Christopher J Wilds
@es
Christopher J Wilds
@nl
Christopher J Wilds
@sl
type
label
Christopher J Wilds
@ast
Christopher J Wilds
@en
Christopher J Wilds
@es
Christopher J Wilds
@nl
Christopher J Wilds
@sl
prefLabel
Christopher J Wilds
@ast
Christopher J Wilds
@en
Christopher J Wilds
@es
Christopher J Wilds
@nl
Christopher J Wilds
@sl
P1053
K-4012-2013
P106
P21
P31
P3829
P496
0000-0002-0336-4753