Structure and dynamics of the pore of inwardly rectifying K(ATP) channels.
about
A family of putative Kir potassium channels in prokaryotesIon selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channelsATP interaction with the open state of the K(ATP) channel.Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channelATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.KATP channels gated by intracellular nucleotides and phospholipids.Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide bindingMutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.The I182 region of k(ir)6.2 is closely associated with ligand binding in K(ATP) channel inhibition by ATPMovement of the C-helix during the gating of cyclic nucleotide-gated channels.The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.Concerted gating mechanism underlying KATP channel inhibition by ATP.A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.CantĂș syndrome resulting from activating mutation in the KCNJ8 geneFlexibility of the Kir6.2 inward rectifier K(+) channel poreCharacterization of a novel, dominant negative KCNJ2 mutation associated with Andersen-Tawil syndrome.Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?The polyamine binding site in inward rectifier K+ channels.A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore.Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels.Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the poreKinetics of inward-rectifier K+ channel block by quaternary alkylammonium ions. dimension and properties of the inner poreOpen state destabilization by ATP occupancy is mechanism speeding burst exit underlying KATP channel inhibition by ATP.Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis.Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channelElectrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels.A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complicationsBlocker protection by short spermine analogs: refined mapping of the spermine binding site in a Kir channelForced gating motions by a substituted titratable side chain at the bundle crossing of a potassium channel.Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter.Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.Zinc protects renal function during cadmium intoxication in the rat.Control of Kir channel gating by cytoplasmic domain interface interactionsDifferential roles of blocking ions in KirBac1.1 tetramer stability.Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity.Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis.
P2860
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P2860
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels.
description
2000 nß lƫn-bûn
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2000ćčŽăźè«æ
@ja
2000ćčŽè«æ
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@zh-hant
2000ćčŽè«æ
@zh-hk
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@zh-mo
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@zh-tw
2000ćčŽèźșæ
@wuu
2000ćčŽèźșæ
@zh
2000ćčŽèźșæ
@zh-cn
name
Structure and dynamics of the pore of inwardly rectifying K
@nl
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels.
@en
type
label
Structure and dynamics of the pore of inwardly rectifying K
@nl
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels.
@en
prefLabel
Structure and dynamics of the pore of inwardly rectifying K
@nl
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels.
@en
P356
P1476
Structure and dynamics of the pore of inwardly rectifying K(ATP) channels
@en
P2093
C G Nichols
E N Makhina
P304
P356
10.1074/JBC.275.2.1137
P407
P577
2000-01-01T00:00:00Z