about
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseA family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptidesCathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulationCysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticityCharacterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug developmentThe importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine proteaseThioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages.Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidasesHelminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination.Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouseHelminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression.Fasciola hepatica vaccine: we may not be there yet but we're on the right roadFasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.Helminths at mucosal barriers--interaction with the immune system.Helminth pathogen cathepsin proteases: it's a family affair.An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.Fasciola hepatica: the therapeutic potential of a worm secretome.Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development.A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease.Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases.The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.Helminth defence molecules-immunomodulators designed by parasites!Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages.Antimicrobial peptides: utility players in innate immunity.Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells.Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase.The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.The enigmatic asparaginyl endopeptidase of helminth parasites.Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors.Glycerol-induced seizure: involvement of IL-1beta and glutamate.Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine.De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum.The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular eveBiochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica.Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling.Interleukin-1β-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Sheila M Donnelly
@ast
Sheila M Donnelly
@en
Sheila M Donnelly
@es
Sheila M Donnelly
@nl
Sheila M Donnelly
@sl
type
label
Sheila M Donnelly
@ast
Sheila M Donnelly
@en
Sheila M Donnelly
@es
Sheila M Donnelly
@nl
Sheila M Donnelly
@sl
prefLabel
Sheila M Donnelly
@ast
Sheila M Donnelly
@en
Sheila M Donnelly
@es
Sheila M Donnelly
@nl
Sheila M Donnelly
@sl
P106
P21
P31
P496
0000-0003-2005-3698
P569
2000-01-01T00:00:00Z