Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.
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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegansDOC2B acts as a calcium switch and enhances vesicle fusionPositional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretionStructural and functional analysis of tomosyn identifies domains important in exocytotic regulationSyntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.Tomosyn interacts with the SUMO E3 ligase PIASγ.The SNARE protein family of Leishmania majorExocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoformsIn vivo analysis of conserved C. elegans tomosyn domains.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationPlatelet secretion and hemostasis require syntaxin-binding protein STXBP5.Tomosyn expression pattern in the mouse hippocampus suggests both presynaptic and postsynaptic functions.Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory.Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse modelsFriends and foes in synaptic transmission: the role of tomosyn in vesicle priming.Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells.Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.Homozygous mutation of STXBP5L explains an autosomal recessive infantile-onset neurodegenerative disorder.SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.SNAREing the basis of multicellularity: consequences of protein family expansion during evolution.The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.
P2860
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P2860
Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.
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2005 nî lūn-bûn
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Two distinct genes drive expre ...... with a unique variable domain.
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Two distinct genes drive expre ...... with a unique variable domain.
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Two distinct genes drive expre ...... with a unique variable domain.
@en
Two distinct genes drive expre ...... with a unique variable domain.
@nl
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Two distinct genes drive expre ...... with a unique variable domain.
@en
Two distinct genes drive expre ...... with a unique variable domain.
@nl
P2860
P1476
Two distinct genes drive expre ...... with a unique variable domain
@en
P2093
Désireé Schut
Linda Jacobsen
P2860
P304
P356
10.1111/J.1471-4159.2004.02890.X
P407
P577
2005-02-01T00:00:00Z