A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.
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Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-SBlood pressure and amiloride-sensitive sodium channels in vascular and renal cellsAtomic force microscopy reveals the architecture of the epithelial sodium channel (ENaC)Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition responseActivation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosaProteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.Role of epithelial sodium channels and their regulators in hypertension.Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleftNovel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation.Validation and optimization of novel high-throughput assays for human epithelial sodium channels.Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.Regulation of transport in the connecting tubule and cortical collecting ductGain-of-function variant of the human epithelial sodium channel.Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling.Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.Gasotransmitters: novel regulators of epithelial na(+) transport?Proteases, cystic fibrosis and the epithelial sodium channel (ENaC).Insight into DEG/ENaC channel gating from genetics and structure.Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?Lentiviral small hairpin RNA delivery reduces apical sodium channel activity in differentiated human airway epithelial cells.Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.Protein kinase B alpha (PKBα) stimulates the epithelial sodium channel (ENaC) heterologously expressed in Xenopus laevis oocytes by two distinct mechanisms.Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).A Missense Mutation in the Extracellular Domain of αENaC Causes Liddle Syndrome.Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase.A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect.Functional and structural determinants of reverse operation in the pH-dependent oligopeptide transporter PepT1.Residues R282 and D341 act as electrostatic gates in the proton-dependent oligopeptide transporter PepT1.Mapping allosteric linkage to channel gating of extracellular domains in the human epithelial sodium channel.Epithelial Na+ Channel Regulation by Extracellular and Intracellular Factors.Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.
P2860
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P2860
A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.
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2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-my
2010年学术文章
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name
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@en
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@nl
type
label
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@en
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@nl
prefLabel
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@en
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@nl
P2093
P2860
P50
P1476
A mutation of the epithelial s ...... d reduces Na+ self inhibition.
@en
P2093
Alexei Diakov
Anja Tzschoppe
Christoph Korbmacher
Harry Cuppens
Jean-Jaques Cassiman
Judit Korbmacher
Jörg Dötsch
P2860
P304
P356
10.1113/JPHYSIOL.2009.180224
P407
P577
2010-03-01T00:00:00Z