Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.

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http://www.wikidata.org/entity/Q42655101
Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia.Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.Tirapazamine-cisplatin: the synergyCisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatinTaking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.Preclinical analysis of resistance and cross-resistance to low-dose metronomic chemotherapy.Comparison of the effectiveness of tirapazamine and carbogen with nicotinamide in enhancing the response of a human tumor xenograft to fractionated irradiation.DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.
P2860

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.

Item
http://www.wikidata.org/entity/Q42655101
description
1997 nî lūn-bûn
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1997年の論文
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1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年学术文章
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1997年學術文章
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1997年學術文章
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1997年學術文章
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name
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@nl
type
label
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@nl
prefLabel
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@nl
P1433
P1476
P2093
P2888
P304
P31
P356
P433
P478
P50
P577
P6179
P698
P921
P356
P1433
P1476
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
P2093
P2888
P304
P31
P356
P433
P478
P50
P577
P6179
P698
P921