Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.
about
Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia.Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin.Tirapazamine-cisplatin: the synergyCisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatinTaking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.Preclinical analysis of resistance and cross-resistance to low-dose metronomic chemotherapy.Comparison of the effectiveness of tirapazamine and carbogen with nicotinamide in enhancing the response of a human tumor xenograft to fractionated irradiation.DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.
P2860
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P2860
Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
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1997年学术文章
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1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
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1997年學術文章
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name
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@nl
type
label
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@nl
prefLabel
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@nl
P2093
P356
P1476
Pharmacokinetics of the hypoxi ...... n strategy in a phase I trial.
@en
P2093
Eckhardt N
Greenslade D
Rampling R
Robin H Jr
von Roemeling R
P2888
P356
10.1007/S002800050617
P50
P577
1997-01-01T00:00:00Z
P6179
1014732647