The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol.
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Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseasePlasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivityBlocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.Phospholipid and sphingolipid metabolism in Leishmania.Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it.myo-Inositol-1-phosphate synthase is required for polar auxin transport and organ development.Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal ActivityIdentification of a novel lipin homologue from the parasitic protozoan Trypanosoma brucei.Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucoseGPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat.Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth.25 years of African trypanosome research: From description to molecular dissection and new drug discoverymyo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei.The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.Lipidomic analysis of bloodstream and procyclic form Trypanosoma bruceiLipid metabolism in Trypanosoma bruceiA novel phospholipase from Trypanosoma bruceiLipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexansThe ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei.Identification of essential and non-essential protein kinases by a fusion PCR method for efficient production of transgenic Trypanosoma brucei.Trypanosoma brucei: a model micro-organism to study eukaryotic phospholipid biosynthesis.Lipid topogenesis--35years on.Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection.A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathwayChemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.Lipidomics and anti-trypanosomatid chemotherapy.Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei.Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma bruceiThe essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei.GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei.Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei.
P2860
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P2860
The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
@zh-my
2006年学术文章
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2006年學術文章
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name
The glycosylphosphatidylinosit ...... de novo synthesis of inositol.
@en
type
label
The glycosylphosphatidylinosit ...... de novo synthesis of inositol.
@en
prefLabel
The glycosylphosphatidylinosit ...... de novo synthesis of inositol.
@en
P2860
P921
P1476
The glycosylphosphatidylinosit ...... de novo synthesis of inositol.
@en
P2093
Kirstee L Martin
Terry K Smith
P2860
P304
P356
10.1111/J.1365-2958.2006.05216.X
P407
P577
2006-07-01T00:00:00Z