about
Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human ErythrocytesUse of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coliPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesComparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase.Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels.Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasitesThermo-responsive non-woven scaffolds for "smart" 3D cell culture.A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tailDiscovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities.A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell linesNowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study.Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.Sustainable malaria control: transdisciplinary approaches for translational applications.Heterologous expression of plasmodial proteins for structural studies and functional annotation.Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasitesCo-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum.Resisting resistance: is there a solution for malaria?Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities.Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters.17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines.Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum.Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities.Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis.Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum.In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species.Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum.Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling.Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy.
P50
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P50
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-Marie Birkholtz
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Lyn-marie Birkholtz
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P1053
E-2939-2010
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P1153
6507990190
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P31
P3829
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0000-0001-5888-2905