Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors
about
In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziReversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides.Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates.S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.Dual substrate recognition of aminotransferases.Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.Cysteine cathepsins S and L modulate anti-angiogenic activities of human endostatin.Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides.Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi.Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes.Structural determinants of specificity in the cysteine protease cruzain.Biotin-labelled peptidyl diazomethane inhibitors derived from the substrate-like sequence of cystatin: targeting of the active site of cruzipain, the major cysteine proteinase of Trypanosoma cruzi.Probing cathepsin K activity with a selective substrate spanning its active site.Subsite specificity of trypanosomal cathepsin L-like cysteine proteases. Probing the S2 pocket with phenylalanine-derived amino acids.Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L.Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana.Substrate inhibition of cruzipain is not affected by the C-terminal domain.Inhibition of trypanosomal cysteine proteinases by their propeptides.
P2860
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P2860
Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Investigation of the substrate ...... ived substrates and inhibitors
@en
Investigation of the substrate ...... ived substrates and inhibitors
@nl
type
label
Investigation of the substrate ...... ived substrates and inhibitors
@en
Investigation of the substrate ...... ived substrates and inhibitors
@nl
prefLabel
Investigation of the substrate ...... ived substrates and inhibitors
@en
Investigation of the substrate ...... ived substrates and inhibitors
@nl
P2093
P2860
P356
P1433
P1476
Investigation of the substrate ...... ived substrates and inhibitors
@en
P2093
Gauthier F
Juliano MA
Lalmanach G
Scharfstein J
P2860
P304
P356
10.1042/BJ3130951
P407
P478
313 ( Pt 3)
P577
1996-02-01T00:00:00Z