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The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysisCrystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and ProcessingMammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early developmentSynthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule.The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central MetabolismA zebrafish in vivo phenotypic assay to identify 3-aminothiophene-2-carboxylic acid-based angiogenesis inhibitors.Molecular interaction of α-conotoxin RgIA with the rat α9α10 nicotinic acetylcholine receptor.Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes.Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.Interaction of Lambda- and Delta-[Ru(bpy)2(pbmz)](PF6)2 with the oligonucleotide duplex d(CGCGAATTCGCG)2.Synthesis and characterization of ruthenium(II)-oligopyridine-peptide conjugates. Interactions of the diasteromeres Δ- and Λ-[Ru(bpy)2(4-COY-4'-Mebpy)]Cl2 (Y=Gly-Lys(1)-Lys(2)CONH2, Lys(1)-Gly-Lys(2)CONH2, Lys(1)-Lys(2)-GlyCONH2) with the oligonucleCritical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs.3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties.Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects.Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: structural requirements for potency.Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.Molecular recognition of N-acetyltryptophan enantiomers by β-cyclodextrin.Direct modulation of T-box riboswitch-controlled transcription by protein synthesis inhibitors.Novel selective inhibitors of aminopeptidases that generate antigenic peptides.Study of the inclusion of the (R)- and (S)-camphor enantiomers in alpha-cyclodextrin by X-ray crystallography and molecular dynamics.Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor.Mononuclear metal complexes with piroxicam: synthesis, structure and biological activity.Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.Structures of the Peptidoglycan N-Acetylglucosamine Deacetylase Bc1974 and Its Complexes with Zinc Metalloenzyme Inhibitors.Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.Identification of Novel Melanin Synthesis Inhibitors From Crataegus pycnoloba Using an in Vivo Zebrafish Phenotypic Assay.Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.Synthesis of 5,6-spiroethers and evaluation of their affinities for the bacterial A site.Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.Preparation, Structure Determination and Cytotoxicity of the PdII·Bleomycin A2 Complex
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Athanasios Papakyriakou
@ast
Athanasios Papakyriakou
@en
Athanasios Papakyriakou
@es
Athanasios Papakyriakou
@nl
type
label
Athanasios Papakyriakou
@ast
Athanasios Papakyriakou
@en
Athanasios Papakyriakou
@es
Athanasios Papakyriakou
@nl
altLabel
Thanos Papakyriakou
@en
prefLabel
Athanasios Papakyriakou
@ast
Athanasios Papakyriakou
@en
Athanasios Papakyriakou
@es
Athanasios Papakyriakou
@nl
P1053
K-7033-2012
P106
P1153
7801330433
P21
P31
P3829
P496
0000-0003-3931-6232