Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases. - Wikidata - wikimedia - TriplyDB

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

http://www.wikidata.org/entity/Q42712897

about

Synthesis of lysine methyltransferase inhibitors Influence of Repressive Histone and DNA Methylation upon D4Z4 Transcription in Non-Myogenic Cells Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum Epigenetic drugs against cancer: an evolving landscape.The promise and peril of chemical probes.SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).Selective inhibitors of protein methyltransferases Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update.The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia.H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus.Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4.P450-Mediated Coupling of Indole Fragments To Forge Communesin and Unnatural Isomers.Mechanistic and chiroptical studies on the desulfurization of epidithiodioxopiperazines reveal universal retention of configuration at the bridgehead carbon atoms.The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.Perspectives on natural product epigenetic modulators in chemical biology and medicine.Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.Targeting the histone orthography of cancer: drugs for writers, erasers and readers.Targeting chromatin to improve radiation response.Inhibitors of Protein Methyltransferases and Demethylases.Cellular analysis of the action of epigenetic drugs and probes.A chemical probe toolbox for dissecting the cancer epigenome.Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90.Towards natural mimetics of metformin and rapamycin.Non-radioactive protein lysine methyltransferase microplate assay based on reading domains.Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis.Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy.Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases"A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro Endothelial Transcriptome in Response to Pharmacological Methyltransferase Inhibition High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

P2860

Q26799953-AF83D079-85C4-4F27-9319-4CDE46D2C7EE Q28553207-7DF2BC60-0E96-4FA2-9256-3218BB26D97A Q33720340-3D0F60AF-FF4D-40F3-BA09-19907D90AC22 Q33815674-21E91916-CD26-49E0-99CE-8270DB3D9D93 Q34431964-C7927B1C-E166-493B-BA1D-A623FEDF57FC Q34486195-12E3DBC5-53EB-46AE-88FE-85AA4283BBAD Q34766981-F9747054-5E12-4BAE-AECB-EA0F670DC567 Q34778239-1B47B003-24C3-4BA9-9CD8-2F2F204F5060 Q35135783-0582330A-6A47-44AD-9928-C98F180B8D10 Q35726371-0C93EE0D-F84B-4EAC-A65A-32FC0E67FCB9 Q36239248-EC40B3B3-E14A-4394-91B9-D02311402F33 Q36267373-DFA672AE-AACB-48BA-85DD-4D7F8298D4ED Q36718683-2704EF13-1050-4F09-9081-E3DEDB682180 Q36833432-84200F91-7D91-41DB-AD6C-75B9F21A7C48 Q37184261-F7F173E6-6BB2-4CF1-A211-0C2F88F6C5DD Q37489578-2C2C7790-EA70-49A9-86F9-F1A47784C64B Q37737903-422FB760-180C-4E77-9A2D-57B2B6B35EB1 Q38080414-52D5A0CD-1D34-4B60-A2F4-310F35DAB15E Q38132808-24F1FFF1-B5F2-4216-86F6-5B8389EBC8AB Q38231327-440CD61F-B6DA-4510-8138-F37ECF532E8E Q38290243-F9988396-1EC5-4370-B35F-3F3D52CA131D Q38740496-83F429A3-AD5A-46C0-B2EF-E4A5B0055C70 Q39077976-0DB6F63D-73D7-4486-BF97-2891931ADEA5 Q39147132-17C10C74-F322-458C-9657-4B95D80ECEEB Q42434145-CCEBBB0E-960F-48E3-9A32-46BAAA1E1132 Q47140599-DBF574A6-5414-4121-B011-0F091B83FC1A Q50996460-951C1CA9-9F25-4E67-AC52-7242B7D122E9 Q52567256-F6647ACD-302E-4F3C-93D6-8139F9CA2275 Q52581847-18517036-2E70-4340-8EB5-A0299D11E1E1 Q57824358-164084DF-68B1-40CE-B0E9-6BA18DC9058F Q58002185-43D2A665-237F-4FCB-ADBC-33A6DA18E898 Q58049788-6B353EF6-8946-4DC8-BC0B-E2C9CA2C05A1 Q58977715-91CB9E0B-E462-451F-ACC9-E6F9576CFB90

P2860

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

http://www.wikidata.org/entity/Q42712897

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@en

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@nl

type

label

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@en

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@nl

prefLabel

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@en

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@nl

P1433

Q42712897-CD5C8E7C-E1B6-42C7-9AC2-53860D69B1EA

P1476

Q42712897-E8222390-5F9B-45E6-BB0C-968C1F86CCE1

P2093

Q42712897-363F8943-6726-43FF-85C4-1807B668E96C

Q42712897-512D0749-6C20-40AE-ACCB-D89E7AEDBA9A

Q42712897-5676C9C2-2212-4ACF-9756-F1FDA28A855E

Q42712897-E7FBDA6B-FB19-4097-8DEF-DA72AD91CC6F

P2860

Q42712897-371A4B0E-971E-4580-B172-616686A9277A

Q42712897-6457D0BC-230D-464C-AA28-CCFE67886271

Q42712897-6C64CC2F-CC40-4332-8E22-4500A8790511

Q42712897-80DB2F9A-5AF3-4933-B8CD-88F280550CC9

Q42712897-A3DEBAC7-4B30-482E-AA61-2F94AC9163A5

Q42712897-BD6A45EE-04B7-4437-AE0E-1F54D2B97AFF

Q42712897-EA30076E-7AE0-4B47-AEA8-25A9B7E456D9

P2888

Q42712897-018CDF12-8295-4229-A89D-00027C14BD9F

P304

Q42712897-E864AB4A-5BE6-4D47-A802-F2B3E1D5A113

P31

Q42712897-E97378FF-AE17-4A1B-9A50-B12538355290

P356

Q42712897-961E07DA-1CD1-4F26-822C-8B4C9A01D77D

P433

Q42712897-EFC3660B-EE1B-4672-BD1F-E69CBC072BA0

P478

Q42712897-830D4C4E-51E3-4F50-9154-7AB15C1A73BF

P577

Q42712897-404623BD-C52E-4E79-A08D-14983A1B8A56

P6179

Q42712897-0576A41F-D9EB-4DCE-B016-7503CDD4EA21

P698

Q42712897-9E49740D-FD64-4EDF-9810-F74C512D2B88

P356

P1433

Nature Chemical Biology

P1476

Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

@en

P2093

Fanny L Cherblanc

http://www.w3.org/2001/XMLSchema#string

Kathryn L Chapman

http://www.w3.org/2001/XMLSchema#string

Matthew J Fuchter

http://www.w3.org/2001/XMLSchema#string

Robert Brown

http://www.w3.org/2001/XMLSchema#string

P2860

The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase.

Current limitations and future opportunities for epigenetic therapies.

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.

Protein methyltransferases as a target class for drug discovery.

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity.

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

P2888

P304

136-137

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NCHEMBIO.1187

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

9

http://www.w3.org/2001/XMLSchema#string

P577

2013-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P6179

1035831658

http://www.w3.org/2001/XMLSchema#string

P698

23416387

http://www.w3.org/2001/XMLSchema#string