about
Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics.Enzyme stereospecificity as a powerful tool in searching for new enzymes.Carbonyl reduction pathways in drug metabolism.Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance.Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological TreatmentPharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases.Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells.Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors.In vitro metabolism of fenofibric acid by carbonyl reducing enzymes.Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity.Inhibition of nitric oxide synthase prevents muscarinic and purinergic functional changes and development of cyclophosphamide-induced cystitis in the rat.Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3).Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier.The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man.Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity.Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase.Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.Deeper insight into the reducing biotransformation of bupropion in the human liver.Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand.3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs.Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation.Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions.Central composite design as a powerful optimisation technique for enantioresolution of the rac-11-dihydrooracin--the principal metabolite of the potential cytostatic drug oracin.Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration.Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1.Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes.Stereospecific biotransformation of albendazole in mouflon and rat-isolated hepatocytes.Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: phase I of biotransformation.Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep.Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.Albendazole repeated administration induces cytochromes P4501A and accelerates albendazole deactivation in mouflon (Ovis musimon).The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes.Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species.Liver microsomal biotransformation of albendazole in deer, cattle, sheep and pig and some related wild breeds.
P50
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P50
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hulumtues
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հետազոտող
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimir Wsol
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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Vladimír Wsól
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P214
P1053
K-3476-2016
P106
P1153
6701828807
P21
P214
P31
P3829
P496
0000-0003-3745-7648
P691
stk2007405425
P7859
viaf-85198694