about
Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cellsAnalysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic successAssociation between circulating levels of sex steroid hormones and Barrett's esophagus in men: a case-control analysis.Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.Quantitative profiling of human renal UDP-glucuronosyltransferases and glucuronidation activity: a comparison of normal and tumoral kidney tissuesGlucuronidation and the UDP-glucuronosyltransferases in health and disease.Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk.Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment.Assay reproducibility of serum androgen measurements using liquid chromatography-tandem mass spectrometry.BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans.Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer riskIn vitro glucuronidation of fenofibric acid by human UDP-glucuronosyltransferases and liver microsomes.Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics.Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.The R148.3 Gene Modulates Caenorhabditis elegans Lifespan and Fat MetabolismEpigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism.Expression of UGT2B7 is driven by two mutually exclusive promoters and alternative splicing in human tissues: changes from prenatal life to adulthood and in kidney cancer.Modulation of the UGT2B7 enzyme activity by C-terminally truncated proteins derived from alternative splicing.The relative protein abundance of UGT1A alternative splice variants as a key determinant of glucuronidation activity in vitro.Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia.Downregulation of hepatic acetylation of drugs in chronic renal failure.Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway.Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines.The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver.A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid.Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study.Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha.Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial.
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description
chercheuse et professeure d'université
@fr
researcher and university professor
@en
wetenschapper
@nl
հետազոտող
@hy
name
Chantal Guillemette
@ast
Chantal Guillemette
@en
Chantal Guillemette
@es
Chantal Guillemette
@fr
Chantal Guillemette
@nl
Chantal Guillemette
@sl
type
label
Chantal Guillemette
@ast
Chantal Guillemette
@en
Chantal Guillemette
@es
Chantal Guillemette
@fr
Chantal Guillemette
@nl
Chantal Guillemette
@sl
prefLabel
Chantal Guillemette
@ast
Chantal Guillemette
@en
Chantal Guillemette
@es
Chantal Guillemette
@fr
Chantal Guillemette
@nl
Chantal Guillemette
@sl
P108
P1153
7003526245
P21
P213
0000 0003 5083 4735
P2798
P31
P3835
chantal-guillemette3
P496
0000-0002-1113-1212