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A Systemized Approach to Investigate Ca(2+) Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived CardiomyocytesStable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticidesRight ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate.Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channelGating of the native and purified cardiac SR Ca(2+)-release channel with monovalent cations as permeant speciesCharged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channelBlock of the ryanodine receptor channel by neomycin is relieved at high holding potentialsRyanodine-induced structural alterations in the RyR channel suggested by neomycin block.Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2)Voltage-sensitive equilibrium between two states within a ryanoid-modified conductance state of the ryanodine receptor channelRyanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.Functional characterization of the cardiac ryanodine receptor pore-forming region.Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel.The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis.Molecular cloning, characterisation and mRNA expression of the ryanodine receptor from the peach-potato aphid, Myzus persicae.The therapeutic potential of new insights into myocardial excitation-contraction coupling.Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: a possible role in cardiac inotropy.Myocardial calcium signalling and arrhythmia pathogenesis.Activation of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by analogues of sulmazole.The interaction of ryanoids with individual ryanodine receptor channels.An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channelsHow does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?Pharmacological regulators of intracellular calcium release channels.Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gatingRyanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart.Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor.Probing luminal negative charge in the type 3 ryanodine receptor.A possible molecular mechanism for 'stunning' of the myocardium.The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.Regulation of current flow through ryanodine receptors by luminal Ca2+.
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alan J Williams
@ast
Alan J Williams
@en
Alan J Williams
@es
Alan J Williams
@nl
type
label
Alan J Williams
@ast
Alan J Williams
@en
Alan J Williams
@es
Alan J Williams
@nl
prefLabel
Alan J Williams
@ast
Alan J Williams
@en
Alan J Williams
@es
Alan J Williams
@nl
P106
P21
P31
P496
0000-0002-3770-8761