about
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallographyStructural basis for natural lactonase and promiscuous phosphotriesterase activitiesStructure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabunCrystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoximeReactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamicsSlow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatmentPressure- and heat-induced inactivation of butyrylcholinesterase: evidence for multiple intermediates and the remnant inactivation processEffects of hydrostatic pressure on the quaternary structure and enzymatic activity of a large peptidase complex from Pyrococcus horikoshii.Structural data on the aging of diethylphosphoryl-butyrylcholinesterase.Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate.Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serineCombined effects of high hydrostatic pressure and temperature for inactivation of Bacillus anthracis spores.Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior.Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1).Pressure-induced molten globule state of human acetylcholinesterase: structural and dynamical changes monitored by neutron scattering.Thermodynamic arguments for temperature-induced cryptic conformational change of human plasma cholinesterase.Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning.Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvosCharacterization of a novel BCHE "silent" allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium.Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndromeDichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose.Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bondLinear and non-linear pressure dependence of enzyme catalytic parameters.Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity.Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo.Human paraoxonase: a promising approach for pre-treatment and therapy of organophosphorus poisoning.Stabilization of the active form(s) of human paraoxonase by human phosphate-binding protein.Comparison of 5 monoclonal antibodies for immunopurification of human butyrylcholinesterase on Dynabeads: KD values, binding pairs, and amino acid sequences.Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma.PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin.Evolution of and perspectives on therapeutic approaches to nerve agent poisoning.Progress in the development of enzyme-based nerve agent bioscavengers.Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes.Slow-binding inhibition of cholinesterases, pharmacological and toxicological relevance.Emergence of catalytic bioscavengers against organophosphorus agents.Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Patrick Masson
@ast
Patrick Masson
@de
Patrick Masson
@en
Patrick Masson
@es
Patrick Masson
@nl
Patrick Masson
@sl
type
label
Patrick Masson
@ast
Patrick Masson
@de
Patrick Masson
@en
Patrick Masson
@es
Patrick Masson
@nl
Patrick Masson
@sl
prefLabel
Patrick Masson
@ast
Patrick Masson
@de
Patrick Masson
@en
Patrick Masson
@es
Patrick Masson
@nl
Patrick Masson
@sl
P1053
J-3964-2013
P106
P1153
7201603992
P21
P31
P3829
P496
0000-0002-7837-3662