Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.
about
Redefining the viral reservoirs that prevent HIV-1 eradicationIdentification of a cluster of HIV-1 controllers infected with low replicating virusesEvolutionary dynamics of HIV at multiple spatial and temporal scales.Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers.Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controllerGlycoproteomic study reveals altered plasma proteins associated with HIV elite suppressors.Reduced evolutionary rates in HIV-1 reveal extensive latency periods among replicating lineagesHuman immunodeficiency virus type-1 (HIV-1) continues to evolve in presence of broadly neutralizing antibodies more than ten years after infection.HIV-1 continues to replicate and evolve in patients with natural control of HIV infectionFinding a cure for HIV: will it ever be achievable?Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllersAdaptation of CD8 T cell responses to changing HIV-1 sequences in a cohort of HIV-1 infected individuals not selected for a certain HLA allele.HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles.High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors.Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection.Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trialsHost factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs.Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers.Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral ReactivationPressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles.Elevated hypermutation levels in HIV-1 natural viral suppressors.Effect of antiretroviral therapy on HIV reservoirs in elite controllers.Monitoring Integration over Time Supports a Role for Cytotoxic T Lymphocytes and Ongoing Replication as Determinants of Reservoir Size.CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants.HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice.Single-copy assay quantification of HIV-1 RNA in paired cerebrospinal fluid and plasma samples from elite controllersHIV-1 replicative fitness in elite controllers.The implications of viral reservoirs on the elite control of HIV-1 infection.Developing strategies for HIV-1 eradicationCell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load.HIV controllers: a genetically determined or inducible phenotype?Finding a cure for human immunodeficiency virus-1 infection.Multiple Origins of Virus Persistence during Natural Control of HIV Infection.Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor.Success and failure of the cellular immune response against HIV-1.
P2860
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P2860
Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@en
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@nl
type
label
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@en
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@nl
prefLabel
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@en
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@nl
P2093
P2860
P356
P1433
P1476
Control of HIV-1 in elite supp ...... and evolution in plasma virus.
@en
P2093
Joel N Blankson
Justin R Bailey
Karen A O'Connell
Timothy P Brennan
P2860
P304
P356
10.1128/JVI.00548-10
P407
P577
2010-05-05T00:00:00Z